Water-soluble glutamic acid derivatives produced in culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica

Rodríguez, J.P.G.; Bernardi, D.I.; Gubiani, J.R.; De Oliveira, J.M.; Morais-Urano, R.P.; Bertonha, A.F.; Bandeira, K.F.; Bulla, J.I.Q.; Sette, L.D.; Ferreira, A.G.; Batista, J.M.; Silva, T.D.S.; Santos, R.A.D.; Martins, C.H.G.; Lira, S.P.; Cunha, M.G.D.; Trivella, D.B.B.; Grazzia, N.; Gomes, N.E.S.; Gadelha, F.; Miguel, D.C.; Cauz, A.C.G.; Brocchi, M.; Berlinck, R.G.S.

Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342300

Type:	Artigo
Title:	Water-soluble glutamic acid derivatives produced in culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica
Author:	Rodríguez, J.P.G. Bernardi, D.I. Gubiani, J.R. De Oliveira, J.M. Morais-Urano, R.P. Bertonha, A.F. Bandeira, K.F. Bulla, J.I.Q. Sette, L.D. Ferreira, A.G. Batista, J.M. Silva, T.D.S. Santos, R.A.D. Martins, C.H.G. Lira, S.P. Cunha, M.G.D. Trivella, D.B.B. Grazzia, N. Gomes, N.E.S. Gadelha, F. Miguel, D.C. Cauz, A.C.G. Brocchi, M. Berlinck, R.G.S.
Abstract:	A new method of screening was developed to generate 770 organic and water-soluble fractions from extracts of nine species of marine sponges, from the growth media of 18 species of marine-derived fungi, and from the growth media of 13 species of endophytic fungi. The screening results indicated that water-soluble fractions displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome assays. Purification of water-soluble fractions from the growth medium of Penicillium solitum IS1-A provided the new glutamic acid derivatives solitumine A (1), solitumine B (2), and solitumidines A-D (3-6). The structures of compounds 1-6 have been established by analysis of spectroscopic data, chemical derivatizations, and vibrational circular dichroism calculations. Although no biological activity could be observed for compounds 1-6, the new structures reported for 1-6 indicate that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolites
Subject:	Dicroísmo circular
Country:	Estados Unidos
Editor:	American Chemical Society
Rights:	Fechado
Identifier DOI:	10.1021/acs.jnatprod.9b00635
Address:	https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.9b00635
Date Issue:	2020
Appears in Collections:	IB - Artigos e Outros Documentos

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