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Type: Artigo
Title: Water-soluble glutamic acid derivatives produced in culture by Penicillium solitum IS1-A from King George Island, Maritime Antarctica
Author: Rodríguez, J.P.G.
Bernardi, D.I.
Gubiani, J.R.
De Oliveira, J.M.
Morais-Urano, R.P.
Bertonha, A.F.
Bandeira, K.F.
Bulla, J.I.Q.
Sette, L.D.
Ferreira, A.G.
Batista, J.M.
Silva, T.D.S.
Santos, R.A.D.
Martins, C.H.G.
Lira, S.P.
Cunha, M.G.D.
Trivella, D.B.B.
Grazzia, N.
Gomes, N.E.S.
Gadelha, F.
Miguel, D.C.
Cauz, A.C.G.
Brocchi, M.
Berlinck, R.G.S.
Abstract: A new method of screening was developed to generate 770 organic and water-soluble fractions from extracts of nine species of marine sponges, from the growth media of 18 species of marine-derived fungi, and from the growth media of 13 species of endophytic fungi. The screening results indicated that water-soluble fractions displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome assays. Purification of water-soluble fractions from the growth medium of Penicillium solitum IS1-A provided the new glutamic acid derivatives solitumine A (1), solitumine B (2), and solitumidines A-D (3-6). The structures of compounds 1-6 have been established by analysis of spectroscopic data, chemical derivatizations, and vibrational circular dichroism calculations. Although no biological activity could be observed for compounds 1-6, the new structures reported for 1-6 indicate that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolites
Subject: Dicroísmo circular
Country: Estados Unidos
Editor: American Chemical Society
Rights: Fechado
Identifier DOI: 10.1021/acs.jnatprod.9b00635
Date Issue: 2020
Appears in Collections:IB - Artigos e Outros Documentos

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