Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/342245
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampZanão, Tamires Araujo-
dc.contributor.authorunicampLopes, Tátila Martins-
dc.contributor.authorunicampCampos, Brunno Machado de-
dc.contributor.authorunicampYasuda, Clarissa Lin-
dc.contributor.authorunicampCendes, Fernando-
dc.typeArtigopt_BR
dc.titlePatterns of default mode network in temporal lobe epilepsy with and without hippocampal sclerosispt_BR
dc.contributor.authorZanão, T.A.-
dc.contributor.authorLopes, T.M.-
dc.contributor.authorde Campos, B.M.-
dc.contributor.authorYasuda, C.L.-
dc.contributor.authorCendes, F.-
dc.subjectEpilepsia do lobo temporalpt_BR
dc.subject.otherlanguageEpilepsy, Temporal lobept_BR
dc.description.abstractThe default mode network (DMN) consists of the deactivation of specific regions during the performance of cognitive tasks and activation during resting or mind wandering. Several pieces of evidence indicate the impairment of DMN in patients with mesial temporal lobe epilepsy (MTLE). However, most of these studies combined different underlying etiologies, failing to disentangle the influence of seizures and presence and side of hippocampal sclerosis (HS). We included 119 patients with MTLE divided into right-HS (n = 42), left-HS (n = 46), and magnetic resonance imaging (MRI)-negative MTLE (n = 31) and controls (n = 59). All underwent resting-state seed-based functional connectivity (FC), with a seed placed at the posterior cingulate cortex (PCC), an essential node for the DMN. To access group inferences, we used an SPM (Statistical Parametric Mapping) full-factorial model to compare patterns of activation using pairwise comparisons among all groups. Our results indicate a different pattern of DMN FC when controlling for side and presence of HS. The group with right-HS had increased FC in the left angular gyrus and the left middle occipital gyrus, when compared to controls, and increased FC of the left hippocampus when compared to the group with left-HS. The MRI-negative group had increased FC of the left hippocampus, left ventral diencephalon, and left fusiform gyrus as compared to left-HS, but did not show any areas of reduced FC compared to controls. By contrast, the group with left-HS did not show areas of increased FC compared to controls or the right-HS and had reduced FC in the left hippocampus compared to controls. Hence, the right-HS presented increased FC in areas related to the DMN in the left hemisphere; the MRI-negative group also showed increased FC in left-sided structures close to temporal lobe when compared to left-HS, probably indicating engagement in a compensatory system. In a subanalysis considering only the MRI-negative with left-sided EEG (electroencephalogram) subgroup, we found differences against controls, with left angular gyrus more connected in the first group, but no significant differences when compared to the group with left-HS. We conclude that the origin of seizures on the left hemisphere seems to engender a less prominent capacity of recruiting other neighbor areas related to DMN as compared to right-HS and controls. Considering recent studies that have revealed the importance of DMN for cognitive skills and memory, our findings may indicate that deficiencies exhibited by patients with left-HS temporal lobe epilepsy (TLE) in connecting to the DMN could be a surrogate marker of their known worse neuropsychological performance. Further studies with direct comparisons between cognitive tests and FC within the DMN are needed to validate these findings, especially for MRI-negative patientspt_BR
dc.relation.ispartofEpilepsy and behaviorpt_BR
dc.relation.ispartofabbreviationEpilepsy behav.pt_BR
dc.publisher.cityMaryland Heights, MOpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.language.isoengpt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn1525-5050pt_BR
dc.identifier.eissn1525-5069pt_BR
dc.identifier.doi10.1016/j.yebeh.2019.106523pt_BR
dc.identifier.urlhttps://www.epilepsybehavior.com/article/S1525-5050(19)30347-6/fulltextpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2016/10433-0; 2013/ 07559-3pt_BR
dc.date.available2020-05-29T15:04:58Z-
dc.date.accessioned2020-05-29T15:04:58Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-05-29T15:04:58Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:15:10Z : No. of bitstreams: 1 2-s2.0-85073714337.pdf: 1139164 bytes, checksum: daf13fac762e45d82138e50aab42bce0 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-29T15:04:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/342245-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordDefault mode networkpt_BR
dc.subject.keywordMRI-negative temporal lobe epilepsypt_BR
dc.subject.keywordHippocampuspt_BR
dc.subject.keywordNeuroimagept_BR
dc.identifier.source2-s2.0-85073714337pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-1261-8257pt_BR
dc.creator.orcid0000-0001-9084-7173pt_BR
dc.creator.orcid0000-0001-9336-9568pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid106523pt_BR
Appears in Collections:FCM - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-85073714337.pdf1.11 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.