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Type: Artigo
Title: Mechanisms and biomarker candidates in pterygium development
Author: Viana Wanzeler, Ana Claudia
Franca Barbosa, Italo Antunes
Duarte, Bruna
Borges, Daniel;
Barbosa, Eduardo Buzolin
Kamiji, Danielle
Gomes Huarachi, Delma Regina
de Melo, Monica Barbosa
Alves, Monica
Abstract: Pterygium pathogenesis has been mainly associated with UV light exposure; however, this association remains quite controversial. The complete mechanism of pterygium also remains to be clarified. Factors such as inflammation, viral infection, oxidative stress, DNA methylation, inflammatory mediators, extracellular matrix modulators, apoptotic and oncogenic proteins, loss of heterozygosity, microsatellite instability, lymphangiogenesis, epithelial-mesenchymal cell transition, and alterations in cholesterol metabolism have been identified as causes. Several studies aimed to clarify the molecular mechanisms underlying the growth and proliferation of pterygium. Understanding its molecular basis provides new potential therapeutic targets for its prevention and treatment. A comprehensive search of the databases, namely, MedLine, EMBASE, and LILACS, was conducted with the following key words: pterygium, epidemiology, pathogenesis, biomarkers, and review. This review describes the epidemiology, clinical presentation, and current investigation of biological mediators involved in pterygium development
Subject: Pterígio
Marcadores biológicos
Country: Brasil
Editor: Conselho Brasileiro de Oftalmologia
Rights: Aberto
Identifier DOI: 10.5935/0004-2749.20190103
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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