Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/341945
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampRosa, Paulo César Pires-
dc.typeArtigopt_BR
dc.titleSynadenium umbellatum and the ehrlich's solid tumor treatment assessment of inflammatory regulators (transforming growth factor protein-β1 and tumor necrosis factor-α) gene expression, hepatotoxicity and myelotoxicitypt_BR
dc.contributor.authorEmerson, da Silva,-
dc.contributor.authorCamila S., Chagas,-
dc.contributor.authorA., Fonseca, Alexandre L.-
dc.contributor.authorA, Alves, Beatriz da C.-
dc.contributor.authorIzilda, Bagatin,-
dc.contributor.authorF., Perazzo, Fábio-
dc.contributor.authorPaulo, Rosa,-
dc.contributor.authorDavid, Feder,-
dc.contributor.authorA., Fonseca, Fernando Luiz-
dc.subjectAgentes antineoplásicospt_BR
dc.subjectHemoglobinaspt_BR
dc.subject.otherlanguageAntineoplastic agentspt_BR
dc.subject.otherlanguageHemoglobinspt_BR
dc.description.abstractStudies have been attributed to cancer treatment, including the potential of several plants with putative anticancer activity. Among these is “Cola-note” (Synadenium umbellatum). We evaluated the effects of macerated S umbellatum at a concentration of 10 mg/kg in Bagg albino strain c mice and its myelotoxic, hepatotoxic, and antitumor activity as well as the expression of inflammatory genes (TGF-β1 and TNF-α). Cells from Ehrlich tumor were implanted in the dorsolateral region of 8 mice of the Bagg albino strain c mice; these animals were divided into control (treated with NaCl 0.9%) and treatment group (treated with macerated Cola-Nota 10 mg/kg). Treatment group animals showed no hepatotoxicity, but a potential myelotoxicity. The results suggest that treatment with Cola-Note macerate causes a decrease in expression of TNF-α and an increased expression of TGF-β1. The S umbellatum (10 mg/kg) is shown to be effective in reducing the concentration of neoplastic cachexia, but there was no antitumor activitypt_BR
dc.relation.ispartofEuropean journal of oncology pharmacypt_BR
dc.relation.ispartofabbreviationEJOPpt_BR
dc.publisher.countryBélgicapt_BR
dc.publisherPharma Publishing & Media Europept_BR
dc.date.issued2019-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume2pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpagee9pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn1783-3914pt_BR
dc.identifier.doi10.1097/OP9.0000000000000009pt_BR
dc.identifier.urlhttps://journals.lww.com/ejop/Fulltext/2019/03000/Synadenium_umbellatum_and_the_Ehrlich_s_solid.1.aspxpt_BR
dc.date.available2020-05-21T19:12:02Z-
dc.date.accessioned2020-05-21T19:12:02Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-05-21T19:12:02Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:18:07Z : No. of bitstreams: 1 2-s2.0-85069515702.pdf: 358360 bytes, checksum: 14ae973da6e555d853d8e0b1f79cdcc5 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-21T19:12:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341945-
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordPlant extractpt_BR
dc.subject.keywordSynadenium umbellatum extractpt_BR
dc.subject.keywordAnimal modelpt_BR
dc.subject.keywordEhrlich ascites tumorpt_BR
dc.identifier.source2-s2.0-85069515702pt_BR
dc.creator.orcid0000-0003-3665-8878pt_BR
dc.type.formArtigo originalpt_BR
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