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Type: Artigo
Title: Synadenium umbellatum and the ehrlich's solid tumor treatment assessment of inflammatory regulators (transforming growth factor protein-β1 and tumor necrosis factor-α) gene expression, hepatotoxicity and myelotoxicity
Author: Emerson, da Silva,
Camila S., Chagas,
A., Fonseca, Alexandre L.
A, Alves, Beatriz da C.
Izilda, Bagatin,
F., Perazzo, Fábio
Paulo, Rosa,
David, Feder,
A., Fonseca, Fernando Luiz
Abstract: Studies have been attributed to cancer treatment, including the potential of several plants with putative anticancer activity. Among these is “Cola-note” (Synadenium umbellatum). We evaluated the effects of macerated S umbellatum at a concentration of 10 mg/kg in Bagg albino strain c mice and its myelotoxic, hepatotoxic, and antitumor activity as well as the expression of inflammatory genes (TGF-β1 and TNF-α). Cells from Ehrlich tumor were implanted in the dorsolateral region of 8 mice of the Bagg albino strain c mice; these animals were divided into control (treated with NaCl 0.9%) and treatment group (treated with macerated Cola-Nota 10 mg/kg). Treatment group animals showed no hepatotoxicity, but a potential myelotoxicity. The results suggest that treatment with Cola-Note macerate causes a decrease in expression of TNF-α and an increased expression of TGF-β1. The S umbellatum (10 mg/kg) is shown to be effective in reducing the concentration of neoplastic cachexia, but there was no antitumor activity
Subject: Agentes antineoplásicos
Country: Bélgica
Editor: Pharma Publishing & Media Europe
Rights: Fechado
Identifier DOI: 10.1097/OP9.0000000000000009
Date Issue: 2019
Appears in Collections:FCF - Artigos e Outros Documentos

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