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http://repositorio.unicamp.br/jspui/handle/REPOSIP/341945
Type: | Artigo |
Title: | Synadenium umbellatum and the ehrlich's solid tumor treatment assessment of inflammatory regulators (transforming growth factor protein-β1 and tumor necrosis factor-α) gene expression, hepatotoxicity and myelotoxicity |
Author: | Emerson, da Silva, Camila S., Chagas, A., Fonseca, Alexandre L. A, Alves, Beatriz da C. Izilda, Bagatin, F., Perazzo, Fábio Paulo, Rosa, David, Feder, A., Fonseca, Fernando Luiz |
Abstract: | Studies have been attributed to cancer treatment, including the potential of several plants with putative anticancer activity. Among these is “Cola-note” (Synadenium umbellatum). We evaluated the effects of macerated S umbellatum at a concentration of 10 mg/kg in Bagg albino strain c mice and its myelotoxic, hepatotoxic, and antitumor activity as well as the expression of inflammatory genes (TGF-β1 and TNF-α). Cells from Ehrlich tumor were implanted in the dorsolateral region of 8 mice of the Bagg albino strain c mice; these animals were divided into control (treated with NaCl 0.9%) and treatment group (treated with macerated Cola-Nota 10 mg/kg). Treatment group animals showed no hepatotoxicity, but a potential myelotoxicity. The results suggest that treatment with Cola-Note macerate causes a decrease in expression of TNF-α and an increased expression of TGF-β1. The S umbellatum (10 mg/kg) is shown to be effective in reducing the concentration of neoplastic cachexia, but there was no antitumor activity |
Subject: | Agentes antineoplásicos Hemoglobinas |
Country: | Bélgica |
Editor: | Pharma Publishing & Media Europe |
Rights: | Fechado |
Identifier DOI: | 10.1097/OP9.0000000000000009 |
Address: | https://journals.lww.com/ejop/Fulltext/2019/03000/Synadenium_umbellatum_and_the_Ehrlich_s_solid.1.aspx |
Date Issue: | 2019 |
Appears in Collections: | FCF - Artigos e Outros Documentos |
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2-s2.0-85069515702.pdf | 349.96 kB | Adobe PDF | View/Open |
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