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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampLancellotti, Marcelo-
dc.typeArtigopt_BR
dc.titleEffect of morinda citrifolia and annona muricata on erhlich tumor cells in swiss albino mice and In Vitro fibroblast cellspt_BR
dc.contributor.authorTorres, Cleber da Silveira-
dc.contributor.authorSantos, Francisnaira da Silva-
dc.contributor.authorGuiguer, Elen Landgraf-
dc.contributor.authorAraújo, Adriano Cressoni de-
dc.contributor.authorBarbalho, Sandra Maria-
dc.contributor.authorBueno, Patrícia Cincotto dos Santos-
dc.contributor.authorSouza, Maricelma Silva Soares de-
dc.contributor.authorAlves, Danilo Antonini-
dc.contributor.authorLancellott, Marcelo-
dc.contributor.authorMoreira, Haydee Maria-
dc.subjectAgentes antineoplásicospt_BR
dc.subjectAscitept_BR
dc.subjectCitotoxicidadept_BR
dc.subjectCarcinoma de Ehrlichpt_BR
dc.subjectFibroblastospt_BR
dc.subject.otherlanguageAntineoplastic agentspt_BR
dc.subject.otherlanguageAscitespt_BR
dc.subject.otherlanguageCytotoxicitypt_BR
dc.subject.otherlanguageCarcinoma, Ehrlich tumorpt_BR
dc.subject.otherlanguageFibroblastspt_BR
dc.description.abstractMorinda citrifolia (MC) and Annona muricata (AM) are popularly used for the treatment of several diseases, including cancer. Our objective was to evaluate the effects of the juice of the MC fruit, and the ethanolic extract of AM leaves on Erhlich tumor cells, in mice and in vitro fibroblastic cells. The animals were divided into G1 and G2: controls; G3: treated with AM, and G4 juice: treated with MC. The animals were subjected to intraperitoneal inoculation of 103 tumor cells and then treated with the plants. G1 and G2 received a saline solution. Cells were grown in RPMI 1640 medium, supplemented with 10% fetal bovine serum, and maintained at 37°C in 5% CO2 atmosphere. After growth, the cells were trypsinized and incubated again. Subsequently, serial dilution of extracts and juice was performed and incubated again for 48 h. We evaluated the ascites growth, the survival rate, and cytotoxicity in fibroblast cells. AM and MC did not interfere in the ascites pattern. MC, but not AM showed significance in the survival rate. Both AM and MC produced cytotoxicity activity in T3T cells. Despite advances in medicine, cancer is still one of the leading causes of death in the world and traditional medications are not always effective. The use of MC may bring beneficial effects to patients since they interfere with different mechanisms of action during carcinogenesis. However, we suggest that further investigations should be performedpt_BR
dc.relation.ispartofJournal of medicinal foodpt_BR
dc.relation.ispartofabbreviationJ med foodpt_BR
dc.publisher.cityNew Rochelle, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherMary Ann Liebertpt_BR
dc.date.issued2019-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume22pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage46pt_BR
dc.description.lastpage51pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn1096-620Xpt_BR
dc.identifier.eissn1557-7600pt_BR
dc.identifier.doi10.1089/jmf.2018.0061pt_BR
dc.identifier.urlhttps://www.liebertpub.com/doi/10.1089/jmf.2018.0061pt_BR
dc.date.available2020-05-21T15:48:55Z-
dc.date.accessioned2020-05-21T15:48:55Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-05-21T15:48:55Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:17:48Z : No. of bitstreams: 1 2-s2.0-85060445426.pdf: 277623 bytes, checksum: fd20deda95711ec7a66142604b7c219c (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-21T15:48:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341921-
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordMorinda citrifolia extractpt_BR
dc.subject.keywordPlant extractpt_BR
dc.subject.keywordIn vitro study; malept_BR
dc.subject.keywordAnnona muricata extractpt_BR
dc.identifier.source2-s2.0-85060445426pt_BR
dc.creator.orcid0000-0003-2573-9138pt_BR
dc.type.formComunicaçãopt_BR
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