Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/341819
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGarcia-Fossa, Fernanda-
dc.contributor.authorunicampDuran Caballero, Nelson Eduardo-
dc.contributor.authorunicampJesus, Marcelo Bispo de-
dc.contributor.authorunicampFávaro, Wagner José-
dc.typeArtigopt_BR
dc.titleCytotoxicity and antitumor activity of biogenic silver nanoparticles against non-muscle invasive bladder cancerpt_BR
dc.contributor.authorFerreira, LAB-
dc.contributor.authorFóssa, FG-
dc.contributor.authorDurán, N-
dc.contributor.authorJesus, MB de-
dc.contributor.authorFávaro, WJ-
dc.subjectMorte celularpt_BR
dc.subjectQuimioterapiapt_BR
dc.subjectCitotoxicidadept_BR
dc.subjectNanotecnologiapt_BR
dc.subjectNanopartículaspt_BR
dc.subject.otherlanguageCell deathpt_BR
dc.subject.otherlanguageChemotherapypt_BR
dc.subject.otherlanguageCytotoxicitypt_BR
dc.subject.otherlanguageNanotechnologypt_BR
dc.subject.otherlanguageNanoparticlespt_BR
dc.description.abstractBladder cancer is the fifth most common form of malignancy in the United States, and for most of the last three decades, the treatment and outcomes for patients with this disease have not changed. Nanomedicine aims to provide the means to target chemotherapies directly and selectively to cancerous cells and enhance their therapeutic efficacy. In this scenario, we employed biogenic Silver Nanoparticles (AgNPs) as an anticancer agent against non-muscle invasive bladder cancer (NMIBC). Bladder cancer was chemically induced with N-methyl-N-nitrosourea (MNU) on C57BL/6Junib female mice and treated by intravesical route with biogenic silver nanoparticles concentrations of 0.5, 0.2, and 0.05 mg/mL. The histopathological analyzes showed the treated with AgNP 0.5 group presented 42.85% of pTa, 28.57% of pTis and 28.57% of pT1, indicating that this treatment was not effective in regressing the neoplastic lesions. MNU + AgNP 0.2 group showed 28.57% of tumor regression, being these animals showed flat hyperplasia (28.57%). Finally, treatment with 0.05 AgNP led to 57.13% of tumor regression, with 14.28% of the animals showing normal urothelium and 42.85% showing flat hyperplasia, considering a benign lesion. Further, to understand the antitumor effect of AgNPs, we evaluated the molecular mechanism of cytotoxicity in human bladder carcinoma 5637 cell. The results showed the dose-time dependent cytotoxicity, and detailed analysis demonstrated the induction of cell death via apoptosis. Besides, we found that AgNP inhibition in cell migration and proliferation. Thus, these findings confirm the antitumor properties of AgNPs and suggest that they may be a cost-effective alternative and promising candidate for the treatment of bladder cancerpt_BR
dc.relation.ispartofJournal of physics : conference seriespt_BR
dc.relation.ispartofabbreviationJPCSpt_BR
dc.publisher.cityBristolpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherIOP Publishingpt_BR
dc.date.issued2019-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume1323pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn1742-6588pt_BR
dc.identifier.eissn1742-6596pt_BR
dc.identifier.doi10.1088/1742-6596/1323/1/012020pt_BR
dc.identifier.urlhttps://iopscience.iop.org/article/10.1088/1742-6596/1323/1/012020/metapt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber402280/2013-0; 2014/50906-9pt_BR
dc.description.sponsordocumentnumberNão tempt_BR
dc.date.available2020-05-20T18:23:51Z-
dc.date.accessioned2020-05-20T18:23:51Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-05-20T18:23:51Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:15:17Z : No. of bitstreams: 1 2-s2.0-85074918871.pdf: 1474457 bytes, checksum: 6deeaec346b2a9cf5e4630cfca2f8d7c (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-20T18:23:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341819-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Química Orgânicapt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordAntitumor propertypt_BR
dc.subject.keywordTarget chemotherapiespt_BR
dc.subject.keywordTherapeutic efficacypt_BR
dc.subject.keywordSilver nanoparticles (AgNps)pt_BR
dc.identifier.source2-s2.0-85074918871pt_BR
dc.creator.orcid0000-0003-2308-0149pt_BR
dc.creator.orcid0000-0001-8372-5143pt_BR
dc.creator.orcid0000-0003-0812-1491pt_BR
dc.creator.orcid0000-0001-5830-8938pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid012020pt_BR
dc.description.sponsorNoteThis work was supported by NanoBioss/Sisnano (CNPq-Brazil, Process number 402280/2013-0), INOMAT (CNPq/MCTI – Process 2014/50906-9; INCT 2014-FAPESP), Brazilian Network of Nanotoxicology (CIGENANOTOX – MCTI/CNPq)pt_BR
Appears in Collections:IQ - Artigos e Outros Documentos
IB - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-85074918871.pdf1.44 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.