Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/341805
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMiyaguti, Natália Angelo da Silva-
dc.contributor.authorunicampOliveira, Sarah Christine Pereira de-
dc.contributor.authorunicampGomes-Marcondes, Maria Cristina Cintra-
dc.typeArtigopt_BR
dc.titleMaternal leucine-rich diet minimises muscle mass loss in tumour-bearing adult rat offspring by improving the balance of muscle protein synthesis and degradationpt_BR
dc.contributor.authorda Silva Miyaguti, Natalia Angelo-
dc.contributor.authorPereira de Oliveira, Sarah Christine-
dc.contributor.authorCintra Gomes-Marcondes, Maria Cristina-
dc.subjectCaquexiapt_BR
dc.subjectLeucinapt_BR
dc.subject.otherlanguageCachexiapt_BR
dc.subject.otherlanguageLeucinept_BR
dc.description.abstractCachexia syndrome can affect cancer patients and new prevention strategies are required. Maternal nutritional supplementation can modify metabolic programming in the offspring, which lasts until adulthood. This could be a good approach against diseases such as cancer. A 3% leucine-rich diet treatment improved muscle protein turnover by modifying the mTOR and proteolytic pathways, thus we analysed whether maternal supplementation could ameliorate muscle protein turnover in adult offspring tumour-bearing rats. Pregnant Wistar rats received a control diet or 3% leucine-rich diet during pregnancy/lactation, and their weaned male offspring received a control diet until adulthood when they were distributed into following groups (n = 7-8 per group): C, Control; W, tumour-bearing; L, without tumour with a maternal leucine-rich diet; and WL, tumour-bearing with a maternal leucine-rich diet. Protein synthesis and degradation were assessed in the gastrocnemius muscle, focusing on the mTOR pathway, which was extensively altered in W group. However, the WL adult offspring showed no decrease in muscle weight, higher food intake, ameliorated muscle turnover, activated mTOR and p70S6K, and maintained muscle cathepsin H and calpain activities. Maternal leucine nutritional supplementation could be a positive strategy to improve muscle protein balance in cancer cachexia-induced muscle damage in adult offspring ratspt_BR
dc.relation.ispartofBiomoleculespt_BR
dc.relation.ispartofabbreviationBiomoleculespt_BR
dc.publisher.cityBaselpt_BR
dc.publisher.countrySuíçapt_BR
dc.publisherMDPIpt_BR
dc.date.issued2019-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume9pt_BR
dc.description.issuenumber6pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissnBaselpt_BR
dc.identifier.doi10.3390/biom9060229pt_BR
dc.identifier.urlhttps://www.mdpi.com/2218-273X/9/6/229pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber302524/2016-9pt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber2014/13334-7; 2017/02739-4; 2017/10809-2pt_BR
dc.date.available2020-05-20T16:55:21Z-
dc.date.accessioned2020-05-20T16:55:21Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-05-20T16:55:21Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:16:36Z : No. of bitstreams: 1 000475301500025.pdf: 2003887 bytes, checksum: f75edeaa0f15ff8d69b730f77010df6d (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-20T16:55:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341805-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordBranched-chain amino acidpt_BR
dc.subject.keywordMuscle protein turnoverpt_BR
dc.identifier.source000475301500025pt_BR
dc.creator.orcid0000-0003-4446-7924pt_BR
dc.creator.orcid0000-0002-5635-7741pt_BR
dc.creator.orcid0000-0002-1713-756Xpt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid229pt_BR
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