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Type: Artigo
Title: Maternal leucine-rich diet minimises muscle mass loss in tumour-bearing adult rat offspring by improving the balance of muscle protein synthesis and degradation
Author: da Silva Miyaguti, Natalia Angelo
Pereira de Oliveira, Sarah Christine
Cintra Gomes-Marcondes, Maria Cristina
Abstract: Cachexia syndrome can affect cancer patients and new prevention strategies are required. Maternal nutritional supplementation can modify metabolic programming in the offspring, which lasts until adulthood. This could be a good approach against diseases such as cancer. A 3% leucine-rich diet treatment improved muscle protein turnover by modifying the mTOR and proteolytic pathways, thus we analysed whether maternal supplementation could ameliorate muscle protein turnover in adult offspring tumour-bearing rats. Pregnant Wistar rats received a control diet or 3% leucine-rich diet during pregnancy/lactation, and their weaned male offspring received a control diet until adulthood when they were distributed into following groups (n = 7-8 per group): C, Control; W, tumour-bearing; L, without tumour with a maternal leucine-rich diet; and WL, tumour-bearing with a maternal leucine-rich diet. Protein synthesis and degradation were assessed in the gastrocnemius muscle, focusing on the mTOR pathway, which was extensively altered in W group. However, the WL adult offspring showed no decrease in muscle weight, higher food intake, ameliorated muscle turnover, activated mTOR and p70S6K, and maintained muscle cathepsin H and calpain activities. Maternal leucine nutritional supplementation could be a positive strategy to improve muscle protein balance in cancer cachexia-induced muscle damage in adult offspring rats
Subject: Caquexia
Country: Suíça
Editor: MDPI
Rights: Aberto
Identifier DOI: 10.3390/biom9060229
Date Issue: 2019
Appears in Collections:IB - Artigos e Outros Documentos

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