Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/341715
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampMaldarine, Juliana dos Santos-
dc.contributor.authorunicampSanches, Bruno Domingos Azevedo-
dc.contributor.authorunicampTaboga, Sebastião Roberto-
dc.typeArtigopt_BR
dc.titlePrenatal exposure to finasteride promotes sex-specific changes in gerbil prostate developmentpt_BR
dc.contributor.authorMaldarine, Juliana S.-
dc.contributor.authorSanches, Bruno D. A.-
dc.contributor.authorCabral, Agata S.-
dc.contributor.authorLima, Maria L. D.-
dc.contributor.authorGuerra, Luiz H. A.-
dc.contributor.authorBaraldi, Carolina M. B.-
dc.contributor.authorCalmon, Marıília F.-
dc.contributor.authorRahal, Paula-
dc.contributor.authorGóes, Rejane M.-
dc.contributor.authorVilamaior, Patricia S. L.-
dc.contributor.authoraboga, Sebastiao R. T-
dc.subjectEstrogêniospt_BR
dc.subjectTestosteronapt_BR
dc.subjectProliferação celularpt_BR
dc.subjectImunofluorescênciapt_BR
dc.subject.otherlanguageEstrogenspt_BR
dc.subject.otherlanguageTestosteronept_BR
dc.subject.otherlanguageCell proliferationpt_BR
dc.subject.otherlanguageImmunofluorescencept_BR
dc.description.abstractFinasteride is a drug that is widely used in the treatment of benign prostatic hyperplasia, hair loss and even as a chemotherapeutic agent in the treatment of prostatic adenocarcinoma. However, its use is known to cause several side effects in adults and it can also cause changes in the embryonic development of the male prostate, which is a cause for concern given the possibility of the accumulation of finasteride in the environment. Nevertheless, no studies have investigated the effects of finasteride on the development of the prostate in females, which occurs in several species of mammals. To evaluate the effects of intrauterine exposure to finasteride (500 mg kg 1 day 1 ) on postnatal prostate development in the Mongolian gerbil in the present study, we used immunohistochemistry, immunofluorescence, serological analysis and three-dimensional reconstruction techniques. Differences were observed in the effects of finasteride on periductal smooth muscle and cell proliferation between the sexes, as well as intersex differences in the presence of the androgen receptor, which was elevated in males, and the oestrogen receptor ERa, which was increased in females. Together, the data indicate that the female prostate has its own hormone dynamics and that there are sex-specific differences in the way in which the female prostate reacts to prenatal exposure to finasteridept_BR
dc.relation.ispartofReproduction, fertility and developmentpt_BR
dc.relation.ispartofabbreviationReprod. fertil. fev.pt_BR
dc.publisher.cityClaytonpt_BR
dc.publisher.countryAustraliapt_BR
dc.publisherCSIROpt_BR
dc.date.issued2019-
dc.language.isoengpt_BR
dc.description.volume31pt_BR
dc.description.issuenumber11pt_BR
dc.description.firstpage1719pt_BR
dc.description.lastpage1729pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn1031-3613pt_BR
dc.identifier.eissn1448-5990pt_BR
dc.identifier.doi10.1071/RD19106pt_BR
dc.identifier.urlhttps://www.publish.csiro.au/rd/RD19106pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber305840/2015-0; 442630/ 2014-0pt_BR
dc.description.sponsordocumentnumber305840/2015-0; 442630/ 2014-0pt_BR
dc.date.available2020-05-19T16:29:49Z-
dc.date.accessioned2020-05-19T16:29:49Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-05-19T16:29:49Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-05-19T16:29:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341715-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordIntrauterine exposurept_BR
dc.subject.keywordAndrogen receptorpt_BR
dc.subject.keywordOestrogen receptor ERapt_BR
dc.subject.keywordSmooth musclept_BR
dc.identifier.source2-s2.0-85068389565pt_BR
dc.creator.orcid0000-0003-0604-1703pt_BR
dc.creator.orcid0000-0002-2139-5991pt_BR
dc.creator.orcid0000-0002-0970-4288pt_BR
dc.type.formArtigopt_BR
dc.description.sponsorNoteThe authors are grateful to Luiz Roberto Falleiros Junior for technical assistance, as well as colleagues at the Laboratory of Microscopy and Microanalysis. This paper forms part of the M.Sc. thesis presented by Juliana S. Maldarine to the Institute of Biology, UNICAMP, in partial fulfilment of the requirements for an M.Sc. degree. This study was funded by grants from FAPESP (2013/15939-0 and 2016/16509-8) and CNPq (National Council of Scientific and Technological Development; 305840/2015-0 and 442630/ 2014-0)pt_BR
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