Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/341681
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGaspar, Rafael Calais-
dc.contributor.authorunicampMuñoz, Vitor Rosetto-
dc.contributor.authorunicampNakandakari, Susana Castelo Branco Ramos-
dc.contributor.authorunicampCrisol, Barbara Moreira-
dc.contributor.authorunicampLenhare, Luciene-
dc.contributor.authorunicampBreda, Leonardo-
dc.contributor.authorunicampBotezelli, José Diego-
dc.contributor.authorunicampSant'Ana, Marcella Ramos-
dc.contributor.authorunicampCintra, Dennys Esper-
dc.contributor.authorunicampMoura, Leandro Pereira de-
dc.contributor.authorunicampRopelle, Eduardo Rochete-
dc.contributor.authorunicampPauli, José Rodrigo-
dc.typeArtigopt_BR
dc.titleAcute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean micept_BR
dc.contributor.authorGaspar, Rafael Calais-
dc.contributor.authorMunoz, Vitor Rosetto-
dc.contributor.authorKuga, Gabriel Keine-
dc.contributor.authorBranco Ramos Nakandakari, Susana Castelo-
dc.contributor.authorCrisol, Barbara Moreira-
dc.contributor.authorLenhare, Lucien-
dc.contributor.authorBreda, Leonardo-
dc.contributor.authorBotezelli, Jose Diego-
dc.contributor.authorSant'Ana, Marcella Ramos-
dc.contributor.authorda Silva, Adelino S. R.-
dc.contributor.authorCintra, Dennys Esper-
dc.contributor.authorde Moura, Leandro Pereira-
dc.contributor.authorRopelle, Eduardo Rochete-
dc.contributor.authorPauli, Jose Rodrigo-
dc.subjectAdiponectinapt_BR
dc.subject.otherlanguageAdiponectinpt_BR
dc.description.abstractAdiponectin is an adipokine that acts in the control of energy homeostasis. The adaptor protein containing the pleckstrin homology domain, phosphotyrosine-binding domain, and leucine zipper motif 1 (APPL1) is a key protein in the adiponectin signaling. The APPL1 mediates a positive effect on the insulin signaling through the interaction with the phosphoinositide 3-kinase (PI3K). Thus, the present study aimed to explore the effects of an acute physical exercise session on the hypothalamic adiponectin signaling. Firstly, using bioinformatics analysis, we found a negative correlation between hypothalamic APPL1 mRNA levels and food consumption in several strains of genetically diverse BXD mice. Also, the mice and the human database revealed a positive correlation between the levels of APPL1 mRNA and PI3K mRNA. At the molecular level, the exercised mice showed increased APPL1 and PI3K (p110) protein contents in the hypothalamus of Swiss mice. Furthermore, the exercise increases co-localization between APPL1 and PI3K p110 predominantly in neurons of the arcuate nucleus of hypothalamus (ARC). Finally, we found an acute exercise session reduced the food intake 5 hr after the end of fasting. In conclusion, our results indicate that physical exercise reduces the food intake and increases some proteins related to adiponectin pathway in the hypothalamus of lean micept_BR
dc.relation.ispartofEuropean journal of neurosciencept_BR
dc.relation.ispartofabbreviationEur. j. neurosci.pt_BR
dc.publisher.cityChichesterpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherWileypt_BR
dc.date.issued2019-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume50pt_BR
dc.description.issuenumber7pt_BR
dc.description.firstpage3181pt_BR
dc.description.lastpage3190pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0953-816Xpt_BR
dc.identifier.eissn1460-9568pt_BR
dc.identifier.doi10.1111/ejn.14490pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/ejn.14490pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber306535/2017-3pt_BR
dc.description.sponsordocumentnumber2016/18488-8pt_BR
dc.date.available2020-05-19T13:15:56Z-
dc.date.accessioned2020-05-19T13:15:56Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-05-19T13:15:56Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-05-19T13:15:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341681-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.contributor.unidadeFaculdade de Ciências Aplicadaspt_BR
dc.subject.keywordAPPL1pt_BR
dc.subject.keywordHypothalamuspt_BR
dc.subject.keywordPhysical exercisept_BR
dc.subject.keywordPI3Kpt_BR
dc.identifier.source000477289100001pt_BR
dc.creator.orcid0000-0002-2208-3527pt_BR
dc.creator.orcid0000-0003-4280-6558pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-2026-2844pt_BR
dc.creator.orcid0000-0003-4379-0471pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-3420-7686pt_BR
dc.creator.orcid0000-0002-7954-5630pt_BR
dc.creator.orcid0000-0003-3211-1058pt_BR
dc.creator.orcid0000-0003-1655-9557pt_BR
dc.creator.orcid0000-0002-6129-1521pt_BR
dc.type.formArtigo de pesquisapt_BR
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