Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/341669
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbn978-3-030-25649-4; 978-3-030-25650-0pt_BR
dc.contributor.authorunicampZuccoli, Giuliana da Silva-
dc.contributor.authorunicampMartins-de-Souza, Daniel-
dc.typeOutro documentopt_BR
dc.titleEffects on glial cell glycolysis in schizophrenia: an advanced aging phenotype?pt_BR
dc.contributor.authorZuccoli, G.S.-
dc.contributor.authorGuest, P.C.-
dc.contributor.authorMartins-de-Souza, D.-
dc.subjectEsquizofreniapt_BR
dc.subjectGlicólisept_BR
dc.subject.otherlanguageSchizophreniapt_BR
dc.subject.otherlanguageGlycolysispt_BR
dc.description.abstractSchizophrenia is a severe and debilitating psychiatric disorder believed to have neurodevelopmental origins. Several studies have associated energy metabolism dysfunction with the disorder, mostly related to glycolysis alterations. Glucose is the obligatory energy substrate of the brain and glycolysis is the first step for its metabolism. This takes place predominantly in glial cells, astrocytes and oligodendrocytes, whereas neurons present a predominant oxidative profile. Thus, glial cells generate either lactate or pyruvate to neurons for ATP production. In addition, some aspects of schizophrenia may reflect an advanced aging phenotype with effects on various neural cell types at different stages of the disease. Given the role of glial cells in brain energy metabolism, the association of glycolysis dysfunction and the accelerated aging of neuronal cells in schizophrenia, studies focusing on those aspects can yield important insights into the causes and implications of the disorder. In turn, this may lead to novel therapeutic strategies for improved treatment of individuals suffering with this disorder.pt_BR
dc.relation.ispartofAdvances in experimental medicine and biologypt_BR
dc.relation.ispartofabbreviationAdv exp med biolpt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherSpringerpt_BR
dc.date.issued2019-
dc.language.isoengpt_BR
dc.description.volume1178pt_BR
dc.description.firstpage25pt_BR
dc.description.lastpage38pt_BR
dc.rightsFechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn0065-2598pt_BR
dc.identifier.eissn2214-8019pt_BR
dc.identifier.doi10.1007/978-3-030-25650-0_2pt_BR
dc.identifier.urlhttps://link.springer.com/chapter/10.1007%2F978-3-030-25650-0_2pt_BR
dc.date.available2020-05-19T12:02:02Z-
dc.date.accessioned2020-05-19T12:02:02Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-05-19T12:02:02Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-05-19T12:02:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341669-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordClozapinept_BR
dc.subject.keywordDisrupted in schizophrenia 1 proteinpt_BR
dc.subject.keywordDizocilpinept_BR
dc.subject.keywordGlucose transporter 1pt_BR
dc.subject.keywordMonocarboxylate transporter 2pt_BR
dc.subject.keywordGlucosept_BR
dc.subject.keywordAgingpt_BR
dc.subject.keywordAstrocytept_BR
dc.subject.keywordBlood brain barrierpt_BR
dc.subject.keywordCell functionpt_BR
dc.subject.keywordCell metabolismpt_BR
dc.subject.keywordCoculturept_BR
dc.subject.keywordDrug targetingpt_BR
dc.subject.keywordEnergy metabolismpt_BR
dc.subject.keywordGlia cellpt_BR
dc.subject.keywordGlycolysispt_BR
dc.subject.keywordMental diseasept_BR
dc.subject.keywordNonhumanpt_BR
dc.subject.keywordOligodendrogliapt_BR
dc.subject.keywordPhenotypept_BR
dc.subject.keywordPriority journalpt_BR
dc.subject.keywordProtein expressionpt_BR
dc.subject.keywordSchizophreniapt_BR
dc.subject.keywordWhite matterpt_BR
dc.subject.keywordGliapt_BR
dc.subject.keywordMetabolismpt_BR
dc.subject.keywordPathophysiologypt_BR
dc.subject.keywordPhenotypept_BR
dc.subject.keywordSchizophreniapt_BR
dc.subject.keywordAgingpt_BR
dc.subject.keywordEnergy Metabolismpt_BR
dc.subject.keywordGlucosept_BR
dc.identifier.source2-s2.0-85071896556pt_BR
dc.creator.orcidorcid.org/0000-0002-7604-9279pt_BR
dc.creator.orcidorcid.org/0000-0003-3595-5846pt_BR
dc.type.formCapítulo de livropt_BR
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