Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/341661
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSposito, Andrei Carvalho-
dc.typeArtigopt_BR
dc.titleChapter three - lipid trafficking in cardiovascular diseasept_BR
dc.contributor.authorSposito, Andrei C.-
dc.contributor.authorZimetti, Francesca-
dc.contributor.authorBarreto, Joaquim-
dc.contributor.authorZanottib, Ilaria-
dc.subjectLipídeospt_BR
dc.subjectDoenças cardiovascularespt_BR
dc.subjectPatologiapt_BR
dc.subject.otherlanguageLipidspt_BR
dc.subject.otherlanguageCardiovascular diseasespt_BR
dc.subject.otherlanguagePathologypt_BR
dc.description.abstractThe reduction of plasma apolipoprotein B (apoB) containing lipoproteins has long been pursued as the main modifiable risk factor for the development of cardiovascular disease (CVD). This has led to an intense search for strategies aiming at reducing plasma apoB-lipoproteins, culminating in reduction of overall CV risk. Despite 3 decades of progress, CVD remains the leading cause of morbidity and mortality worldwide and, as such, new therapeutic targets are still warranted. Clinical and preclinical research has moved forward from the original concept, under which some lipids must be accumulated and other removed to achieve the ideal condition in disease prevention, into the concept that mechanisms that orchestrate lipid movement between lipoproteins, cells and organelles is equally involved in CVD. As such, this review scrutinizes potentially atherogenic changes in lipid trafficking and assesses the molecular mechanisms behind it. New developments in risk assessment and new targets for the mitigation of residual CVD risk are also addressedpt_BR
dc.relation.ispartofAdvances in clinical chemistrypt_BR
dc.relation.ispartofabbreviationAdv clin chempt_BR
dc.publisher.cityMaryland Heightspt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.date.monthofcirculationMaypt_BR
dc.language.isoengpt_BR
dc.description.volume92pt_BR
dc.description.firstpage105pt_BR
dc.description.lastpage140pt_BR
dc.rightsFechadopt_BR
dc.sourceSCOPUSpt_BR
dc.identifier.issn0065-2423pt_BR
dc.identifier.eissn2162-9471pt_BR
dc.identifier.doi10.1016/bs.acc.2019.04.002pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0065242319300289pt_BR
dc.date.available2020-05-19T11:15:58Z-
dc.date.accessioned2020-05-19T11:15:58Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-05-19T11:15:58Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:17:58Z : No. of bitstreams: 1 2-s2.0-85066251825.pdf: 824921 bytes, checksum: 3d1ef0a7c14655533c0b63218198ba06 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-19T11:15:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341661-
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordBloodpt_BR
dc.subject.keywordHumanpt_BR
dc.identifier.source2-s2.0-85066251825pt_BR
dc.creator.orcid0000-0001-7127-2052pt_BR
dc.type.formArtigopt_BR
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