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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampOcchiutto, Marcelo Luís-
dc.contributor.authorunicampCosta, Vital Paulino-
dc.typeArtigopt_BR
dc.titleNanotechnology for medical and surgical glaucoma therapy—a reviewpt_BR
dc.contributor.authorOcchiutto, Marcelo Luís-
dc.contributor.authorMaranhão, Raul C.-
dc.contributor.authorCosta, Vital Paulino-
dc.contributor.authorKonstas, Anastasios G.-
dc.subjectGlaucomapt_BR
dc.subjectNanomedicinapt_BR
dc.subject.otherlanguageGlaucomapt_BR
dc.subject.otherlanguageNanomedicinept_BR
dc.description.abstractGlaucoma is the second leading cause of blindness worldwide. Even though significant advances have been made in its management, currently available antiglaucoma therapies suffer from considerable drawbacks. Typically, the success and efficacy of glaucoma medications are undermined by their limited bioavailability to target tissues and the inadequate adherence demonstrated by patients with glaucoma. The latter is due to a gradual decrease in tolerability of lifelong topical therapies and the significant burden to patients of prescribed stepwise antiglaucoma regimens with frequent dosing which impact quality of life. On the other hand, glaucoma surgery is restricted by the inability of antifibrotic agents to efficiently control the wound healing process without causing severe collateral damage and long-term complications. Evolution of the treatment paradigm for patients with glaucoma will ideally include prevention of retinal ganglion cell degeneration by the successful delivery of neurotrophic factors, anti-inflammatory drugs, and gene therapies. Nanotechnology-based treatments may surpass the limitations of currently available glaucoma therapies through optimized targeted drug delivery, increased bioavailability, and controlled release. This review addresses the recent advances in glaucoma treatment strategies employing nanotechnology, including medical and surgical management, neuroregeneration, and neuroprotectionpt_BR
dc.relation.ispartofAdvances in therapypt_BR
dc.relation.ispartofabbreviationAdv therpt_BR
dc.publisher.cityAucklandpt_BR
dc.publisher.countryNova Zelândiapt_BR
dc.publisherSpringerpt_BR
dc.date.issued2020-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume37pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage155pt_BR
dc.description.lastpage199pt_BR
dc.rightsFechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn0741-238Xpt_BR
dc.identifier.eissn1865-8652pt_BR
dc.identifier.doi10.1007/s12325-019-01163-6pt_BR
dc.identifier.urlhttps://link.springer.com/article/10.1007/s12325-019-01163-6pt_BR
dc.date.available2020-05-18T23:36:01Z-
dc.date.accessioned2020-05-18T23:36:01Z-
dc.description.provenanceSubmitted by Thais de Brito Barroso (tbrito@unicamp.br) on 2020-05-18T23:36:01Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:15:33Z : No. of bitstreams: 1 2-s2.0-85076627552.pdf: 1319902 bytes, checksum: 0dae598d5ef8e90c155eec9ad46fdb3f (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-18T23:36:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2020en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341647-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Oftalmo e Otorrinolaringologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordNanoparticlespt_BR
dc.subject.keywordNanosystemspt_BR
dc.subject.keywordNanotechnologypt_BR
dc.subject.keywordOcular drug deliverypt_BR
dc.subject.keywordOphthamlologypt_BR
dc.identifier.source2-s2.0-85076627552pt_BR
dc.creator.orcid0000-0003-4744-5894pt_BR
dc.creator.orcid0000-0001-6147-4611pt_BR
dc.type.formArtigo de revisãopt_BR
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