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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSousa, Andressa Silva-
dc.contributor.authorunicampSponton, Amanda Christine da Silva-
dc.contributor.authorunicampTrifone, César Bertinato-
dc.contributor.authorunicampDelbin, Maria Andréia-
dc.typeArtigopt_BR
dc.titleAerobic exercise training prevents perivascular adipose tissue-induced endothelial dysfunction in thoracic aorta of obese micept_BR
dc.contributor.authorSousa, Andressa S.-
dc.contributor.authorSponton, Amanda C. S.-
dc.contributor.authorTrifone, Cesar B.-
dc.contributor.authorDelbin, Maria A.-
dc.subjectObesidadept_BR
dc.subjectTecido adiposo perivascularpt_BR
dc.subjectDisfunção endotelialpt_BR
dc.subject.otherlanguageObesitypt_BR
dc.subject.otherlanguageEndothelial dysfunctionpt_BR
dc.description.abstractThe mechanisms underlying the perivascular adipose tissue (PVAT) dysfunction in obesity are closely related to inflammation and oxidative stress. The present study aimed to investigate the effects of aerobic exercise training on PVAT-induced endothelial dysfunction of thoracic aorta of obese mice. Methods: Male mice C57BL6/JUnib (6-7 weeks) were divided into: sedentary (c-SD), trained (c-TR), obese sedentary (o-SD), and obese trained (o-TR). Obesity was induced by 16 weeks of high-fat diet and exercise training of moderate intensity started after 8 weeks of protocol and was performed on a treadmill, 5 days/week, for more 8 weeks, 60 min per session. The vascular responsiveness was performed in thoracic aorta in the absence (PVAT-) or in the presence (PVAT+) of PVAT. We analyzed circulatory parameters, protein expression, vascular nitric oxide (NO) production, and reactive oxygen species (ROS) in PVAT. Results: The maximal responses to acetylcholine (ACh) were reduced in PVAT+ compared with PVAT- rings in the o-SD group, accompanied by an increase in circulating glucose, insulin, resistin, leptin, and TNF-alpha. Additionally, the protein expression of iNOS and generation of ROS were increased in PVAT and production of vascular NO was reduced in the o-SD group compared with c-SD. In the o-TR group, the relaxation response to ACh was completely restored and the circulatory TNF-alpha, iNOS protein expression, and ROS were normalized with increased expression of Mn-SOD in PVAT, resulting in enhanced vascular NO production. Conclusion: The PVAT-induced endothelial dysfunction in thoracic aorta of obese mice, associated with circulatory inflammation and oxidative stress. Aerobic exercise training upregulated the anti-oxidant expression and decreased PVAT oxidative stress with beneficial impact on endothelium-dependent relaxationpt_BR
dc.relation.ispartofFrontiers in physiologypt_BR
dc.publisher.cityLausannept_BR
dc.publisher.countrySuiçapt_BR
dc.publisherFrontiers Research Foundationpt_BR
dc.date.issued2019-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume10pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn1664-042Xpt_BR
dc.identifier.doi10.3389/fphys.2019.01009pt_BR
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fphys.2019.01009/fullpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2013/02960-1pt_BR
dc.date.available2020-05-18T15:41:32Z-
dc.date.accessioned2020-05-18T15:41:32Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-05-18T15:41:32Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:16:50Z : No. of bitstreams: 1 000481451000001.pdf: 2558039 bytes, checksum: bad8d157b4c33a780692f8b0e65dda17 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-18T15:41:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341609-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordAerobic exercise trainingpt_BR
dc.subject.keywordVascular reactivitypt_BR
dc.identifier.source000481451000001pt_BR
dc.creator.orcid0000-0001-6135-2809pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-3537-055Xpt_BR
dc.type.formArtigo de pesquisapt_BR
dc.identifier.articleid1009pt_BR
dc.description.sponsorNoteFAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/02960-1]; FAEPEX [0315/14]pt_BR
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