Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/341598
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGonzález Salazar, Carelis Del Valle-
dc.contributor.authorunicampFranca Junior, Marcondes Cavalcante-
dc.typeArtigopt_BR
dc.titleAre cognitive changes in hereditary spastic paraplegias restricted to complicated forms?pt_BR
dc.contributor.authorJacinto-Scudeiro, Lais Alves-
dc.contributor.authorMachado, Gustavo Dariva-
dc.contributor.authorAyres, Annelise-
dc.contributor.authorBurguez, Daniela-
dc.contributor.authorPolese-Bonato, Marcia-
dc.contributor.authorGonzalez-Salazar, Carelis-
dc.contributor.authorSiebert, Marina-
dc.contributor.authorFranca Junior, Marcondes Cavalcante-
dc.contributor.authorOlchik, Maira Rozenfeld-
dc.contributor.authorMorales Saute, Jonas Alex-
dc.subjectParaplegia espástica hereditáriapt_BR
dc.subjectMemóriapt_BR
dc.subject.otherlanguageSpastic paraplegia, Hereditarypt_BR
dc.subject.otherlanguageMemorypt_BR
dc.description.abstractLittle is known about the cognitive profile of Hereditary Spastic Paraplegias (HSP), where most scientific attention has been given to motor features related to corticospinal tract degeneration. Objectives: We aimed to perform a broad characterization of the cognitive functions of patients with pure and complicated HSP as well as to determine the frequency of abnormal cognitive performances in the studied subtypes. Methods: A two-center cross-sectional case-control study was performed. All individuals underwent cognitive assessment through screening tests (Mini Mental State Examination-MEEM and Montreal Cognitive Assessment-MOCA) and tests to assess specific cognitive functions (Verbal fluency with phonological restriction-FAS; Verbal categorical fluency-FAS-cat and Rey's Verbal Auditory Learning Test-RAVLT). Results: Fifty four patients with genetically confirmed HSP diagnosis, 36 with spastic paraplegia type 4 (SPG4), 5 SPG11, 4 SPG5, 4 cerebrotendinous xanthomatosis (CTX), 3 SPG7 and 2 SPG3A, and 10 healthy, unrelated control subjects, with similar age, sex, and education participated in the study. SPG4 patients had worse performances in MOCA, FAS, FAS-cat, and RAVLT when compared to controls. Most SPG4 patients presented cognitive changes not compatible with dementia, performing poorly in memory, attention and executive functions. SPG5 patients scored lower in executive functions and memory, and SPG7 patients performed poorly on memory tasks. All evaluated cognitive functions were markedly altered in CTX and SPG11 patients. Conclusions: Cognitive abnormalities are frequent in HSP, being more severe in complicated forms. However, cognitive impairments of pure HSPs might impact patients' lives, decreasing families' socioeconomic status and contributing to the overall disease burdenpt_BR
dc.relation.ispartofFrontiers in neurologypt_BR
dc.publisher.cityLausannept_BR
dc.publisher.countrySuíçapt_BR
dc.publisherFrontiers Research Foundationpt_BR
dc.date.issued2019-
dc.date.monthofcirculationMaypt_BR
dc.language.isoengpt_BR
dc.description.volume10pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn1664-2295pt_BR
dc.identifier.doi10.3389/fneur.2019.00508pt_BR
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fneur.2019.00508/fullpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO RIO GRANDE DO SUL - FAPERGSpt_BR
dc.date.available2020-05-18T13:57:12Z-
dc.date.accessioned2020-05-18T13:57:12Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-05-18T13:57:12Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-05-18T13:57:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341598-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordCognitive profilept_BR
dc.subject.keywordExecutive functionpt_BR
dc.identifier.source000468937700001pt_BR
dc.creator.orcid0000-0003-2300-682Xpt_BR
dc.creator.orcid0000-0003-0898-2419pt_BR
dc.type.formArtigo de pesquisapt_BR
dc.identifier.articleid508pt_BR
dc.description.sponsorNoteMCTI/CNPQ/Universal [14/2014 (460941/2014-3)]; FIPE-HCPA [GPPG-HCPA 17-0012]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)CAPES; CNPqNational Council for Scientific and Technological Development (CNPq); Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)Foundation for Research Support of the State of Rio Grande do Sul (FAPERGS); Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)pt_BR
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