Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/341589
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGraça, Felipe Franco da-
dc.contributor.authorunicampRezende, Thiago Junqueira Ribeiro de-
dc.contributor.authorunicampFranca Junior, Marcondes Cavalcante-
dc.typeArtigopt_BR
dc.titleNeuroimaging in hereditary spastic paraplegias: current use and future perspectivespt_BR
dc.contributor.authorda Graca, Felipe Franco-
dc.contributor.authorRibeiro de Rezende, Thiago Junqueira-
dc.contributor.authorRocha Vasconcellos, Luiz Felipe-
dc.contributor.authorPedroso, Jose Luiz-
dc.contributor.authorBarsottini, Orlando Graziani P.-
dc.contributor.authorFranca Junior, Marcondes C.-
dc.subjectRessonância magnéticapt_BR
dc.subjectParaplegia espástica hereditáriapt_BR
dc.subject.otherlanguageMagnetic resonancept_BR
dc.subject.otherlanguageSpastic paraplegia, Hereditarypt_BR
dc.description.abstractHereditary spastic paraplegias (HSP) are a large group of genetic diseases characterized by progressive degeneration of the long tracts of the spinal cord, namely the corticospinal tracts and dorsal columns. Genotypic and phenotypic heterogeneity is a hallmark of this group of diseases, which makes proper diagnosis and management often challenging. In this scenario, magnetic resonance imaging (MRI) emerges as a valuable tool to assist in the exclusion of mimicking disorders and in the detailed phenotypic characterization. Some neuroradiological signs have been reported in specific subtypes of HSP and are therefore helpful to guide genetic testing/interpretation. In addition, advanced MRI techniques enable detection of subtle structural abnormalities not visible on routine scans in the spinal cord and brain of subjects with HSP. In particular, quantitative spinal cord morphometry and diffusion tensor imaging look promising tools to uncover the pathophysiology and to track progression of these diseases. In the current review article, we discuss the current use and future perspectives of MRI in the context of HSPpt_BR
dc.relation.ispartofFrontiers in neurologypt_BR
dc.publisher.cityLausannept_BR
dc.publisher.countrySuíçapt_BR
dc.publisherFrontiers Research Foundationpt_BR
dc.date.issued2019-
dc.date.monthofcirculationJan.pt_BR
dc.language.isoengpt_BR
dc.description.volume9pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn1664-2295pt_BR
dc.identifier.doi10.3389/fneur.2018.01117pt_BR
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fneur.2018.01117/fullpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber303914/2014-9pt_BR
dc.description.sponsordocumentnumber2013/01766-7pt_BR
dc.date.available2020-05-18T12:07:06Z-
dc.date.accessioned2020-05-18T12:07:06Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-05-18T12:07:06Z No. of bitstreams: 0en
dc.description.provenanceMade available in DSpace on 2020-05-18T12:07:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341589-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Neurologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordDiagnosispt_BR
dc.subject.keywordSpinal cordpt_BR
dc.identifier.source000455800200001pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0001-8453-0313pt_BR
dc.creator.orcid0000-0003-0898-2419pt_BR
dc.type.formArtigo de revisãopt_BR
dc.identifier.articleid1117pt_BR
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