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|Title:||Echocardiografic abnormalities in patients with sickle cell/β-thalassemia do not depend on the β-thalassemia phenotype|
|Abstract:||Objectives and methods: We evaluated possible relationships between echocardiographic findings and clinical and laboratory parameters, in a cohort of Brazilian patients diagnosed with sickle cell/β-thalassemia, to better understand the cardiac involvement in this disease. Results: Left atrial (LA)and left ventricular (LV)dilation were found in 19.5 and 11% of patients, respectively; systolic left ventricular dysfunction was present in a single patient. There were no differences in masses and volumes of cardiac chambers comparing Sβ0 with Sβ+ patients, and no relationship between these parameters and specific complications of the disease. However, parameters of altered ventricular geometry were significantly correlated with serum creatinine, hepatic transaminases and bilirubin levels. Moreover, 3 patients presented stroke; they were significantly older [53 (41–56)× 37.5 (18–70), p = 0.048], had higher values of LV posterior wall diastolic thickness [10 (10–11)× 8 (6–14), p = 0.03], LV mass [226 (194–260)× 147 (69–537), p = 0.039]and LA/aortic ratio [1.545 (1.48–1.61)× 1.26 (0.9–1.48), p = 0.032]. Conclusions: Cardiac involvement in this disease does not appear to depend on the thalassemia phenotype. The presence of signs of myocardial remodeling in this group of patients was related to multi-organ impairment and rendered a higher propensity for stroke in older patients, suggesting the need for greater vigilance and control of associated factors|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
HEMO - Artigos e Outros Documentos
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