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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCeseti, Lucas de Moraes-
dc.contributor.authorunicampAlvarez-Martinez, Cristina Elisa-
dc.typeArtigopt_BR
dc.titleDistribution, function and regulation of type 6 secretion systems of xanthomonadalespt_BR
dc.contributor.authorBayer-Santos, Ethel-
dc.contributor.authorCeseti, Lucas de Moraes-
dc.contributor.authorFarah, Chuck Shaker-
dc.contributor.authorAlvarez-Martinez, Cristina Elisa-
dc.subjectPredação (Biologia)pt_BR
dc.subjectEfetores semelhantes a ativadores de transcriçãopt_BR
dc.subjectXanthomonaspt_BR
dc.subject.otherlanguagePredation (Biology)pt_BR
dc.subject.otherlanguageTranscription activator-Like effectorspt_BR
dc.subject.otherlanguageXanthomonaspt_BR
dc.description.abstractMembers of the Xanthomonadales order include several plant pathogens of significant economic and agricultural impact, such as Xanthomonas spp. Type 6 secretion systems (T6SSs) are contractile nanomachines used by many bacterial species to inject protein effectors into target prokaryotic and eukaryotic cells and provide a competitive advantage for bacteria in different environments. Effectors with antibacterial properties include peptidoglycan hydrolases, lipases and phospholipases that break down structural components of the cell envelope, promoting target-cell lysis; and RNases, DNAses, and NADases that affect target-cell metabolism, arresting growth. Effectors with anti-eukaryotic properties are functionally more diverse. The T6SS of Xanthomonas citri is the only example experimentally characterized so far within the Xanthomonadales order and displays anti-eukaryotic function by providing resistance to predation by amoeba. This T6SS is regulated at the transcriptional level by a signaling cascade involving a Ser/Thr kinase and an extracytoplasmic function (ECF) sigma factor. In this review, we performed in silico analyses of 35 genomes of Xanthomonadales and showed that T6SSs are widely distributed and phylogenetically classified into three major groups. In silico predictions identified a series of proteins with known toxic domains as putative T6SS effectors, suggesting that the T6SSs of Xanthomonadales display both anti-prokaryotic and anti-eukaryotic properties depending on the phylogenetic group and bacterial speciespt_BR
dc.relation.ispartofFrontiers in microbiologypt_BR
dc.relation.ispartofabbreviationFront. microbiol.pt_BR
dc.publisher.cityLausannept_BR
dc.publisher.countrySuiçapt_BR
dc.publisherFrontiers Research Foundationpt_BR
dc.date.issued2019-
dc.date.monthofcirculationJulypt_BR
dc.language.isoengpt_BR
dc.description.volume10pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn1664-302Xpt_BR
dc.identifier.doi10.3389/fmicb.2019.01635pt_BR
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fmicb.2019.01635/fullpt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber2017/02178-2; 2017/17303-7; 2018/01852-4; 2018/04553-8; 2017/02318-9pt_BR
dc.date.available2020-05-15T21:06:11Z-
dc.date.accessioned2020-05-15T21:06:11Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-05-15T21:06:11Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:16:39Z : No. of bitstreams: 1 000475803600001.pdf: 2945500 bytes, checksum: 7c48259116f19ce16c31b5f01b94ef30 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-15T21:06:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/341565-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Genética, Evolução e Bioagentespt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordXanthomonadalespt_BR
dc.subject.keywordBacterial killingpt_BR
dc.subject.keywordAmoeba predationpt_BR
dc.identifier.source000475803600001pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-3882-1835pt_BR
dc.type.formArtigo de revisãopt_BR
dc.identifier.articleid1635pt_BR
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