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Type: Artigo
Title: Pomegranate juice and peel extracts are able to inhibit proliferation, migration and colony formation of prostate cancer cell lines and modulate the akt/mtor/s6k signaling pathway
Author: Chaves, Fernanda Machado
Pavan, Isadora Carolina Betim
Silva, Luiz Guilherme Salvino da
Freitas, Lidia Broglio de
Rostagno, Mauricio Ariel
Antunes, Adriane Elisabete Costa
Bezerra, Rosângela Maria Neves
Simabuco, Fernando Moreira
Abstract: Pomegranate (Punica granatum) is known to contain polyphenols with many potential health benefits, including anti-tumoral, anti-inflammatory, and anti-microbial properties. It has been used in popular medicine for cancer treatment, which still represents the major cause of cancer-related deaths in men worldwide. Importantly, pomegranate peels are valuable by-products of the food industry that are rich in polyphenols. Here we report a comparison between juice and peel aqueous extracts in prostate cancer DU-145 and PC-3 cell lines. Both extracts were able to inhibit the proliferation, migration and colony formation of those cells, although peel extracts presented more robust effects compared to juice. Besides, the growth-related mTOR/S6K signaling pathway presented strong inhibition after pomegranate extracts treatment. This study presents evidence that both juice and isolated peel extracts from promegate fruit have important anti-cancer effects against prostate cancer cells, modulating the mTOR/S6K signaling pathway
Subject: Neoplasias da próstata
Country: Estados Unidos
Editor: Springer
Rights: Fechado
Identifier DOI: 10.1007/s11130-019-00776-0
Date Issue: 2020
Appears in Collections:FCA - Artigos e Outros Documentos

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