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|Title:||Using RNA interference for purinoceptor knockdown in vivo|
|Author:||Amorim, Rebeca Padrão|
Cendes, Iscia Teresinha Lopes
Fernandes, Maria Jose da Silva
|Abstract:||RNA interference (RNAi) is a powerful post-transcriptional gene silencing (PTGS) induced by small double-stranded RNA (dsRNA). The method allows silencing of genes of interest by translation inhibition or by mRNA degradation. In this chapter, we provide a brief overview of the mechanisms involved in each step of gene silencing. A nonviral infusion of short siRNA into ventricular system of rats was used to study purinoceptor in the rat brain|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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