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Type: Artigo
Title: Synthesis of the C(7)-C(20) fragment of spirotoamides A, B and C
Author: Rossini, Allan F. C.
Dias, Luiz C.
Abstract: This work describes the preparation of the C(7)-C(20) fragment of spirotoamides A to C in a very elegant fashion, achievement very high levels of stereocontrol. The synthesis has been accomplished by a sequence involving 14 steps (0.36% overall yield, average of 81% for each step) in high diastereo and enantioselectivity, employing, as determining steps, asymmetric Mukaiyama and boron-mediated 1,5-anti promoted aldol reactions between alpha-methyl-beta-hydroxyketones and aldehydes
Subject: Produtos biológicos
Reação aldólica
Country: Brasil
Editor: Sociedade Brasileira de Química
Rights: Aberto
Identifier DOI: 10.21577/0103-5053.20190126
Date Issue: 2019
Appears in Collections:IQ - Artigos e Outros Documentos

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