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|Title:||Synthesis of the C(7)-C(20) fragment of spirotoamides A, B and C|
|Author:||Rossini, Allan F. C.|
Dias, Luiz C.
|Abstract:||This work describes the preparation of the C(7)-C(20) fragment of spirotoamides A to C in a very elegant fashion, achievement very high levels of stereocontrol. The synthesis has been accomplished by a sequence involving 14 steps (0.36% overall yield, average of 81% for each step) in high diastereo and enantioselectivity, employing, as determining steps, asymmetric Mukaiyama and boron-mediated 1,5-anti promoted aldol reactions between alpha-methyl-beta-hydroxyketones and aldehydes|
|Editor:||Sociedade Brasileira de Química|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
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