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Type: Artigo
Title: A simulation study of gold nanoparticles localisation effects on radiation enhancement at the mitochondrion scale
Author: Francis, Z.
Montarou, G.
Incerti, S.
Bernal, M.
Zein, S. A.
Abstract: This paper presents a Monte-Carlo study focusing on the effects of gold nanoparticles on the energy deposition patterns produced by incident photons in the close vicinity of the mitochondrial network modeled as a tube. Spherical shaped gold nanoparticles of 30 nm diameter were placed in a micrometric (10 x 10 x 10 mu m(3)) water phantom containing a tube of 300 nm diameter and 5 mu m length. The tube represented a mitochondrial fragment and nanoparticles were distributed in the water phantom outside the tube. Photons of 120 keV were simulated using the Geant4 Livermore processes and the Geant4-DNA electron processes to account for secondary electrons collisions. The Livermore processes took into account the Auger cascade inside the gold material. A data mining algorithm was then used to analyze the energy deposition clusters inside the water phantom and the tube. A comparison was made between the results obtained for a uniform distribution of nanoparticles and a vesicle distribution model. The results including energy deposition clusters are also compared to dose enhancement ratios.
Subject: Nanopartículas de ouro
Monte Carlo, Método de
Dano ao DNA
Gold nanoparticles
Monte Carlo method
DNA damage
Country: Reino Unido
Editor: Elsevier
Rights: fechado
Identifier DOI: 10.1016/j.ejmp.2019.10.038
Date Issue: 2019
Appears in Collections:IFGW - Artigos e Outros Documentos

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