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|Title:||A simulation study of gold nanoparticles localisation effects on radiation enhancement at the mitochondrion scale|
Zein, S. A.
|Abstract:||This paper presents a Monte-Carlo study focusing on the effects of gold nanoparticles on the energy deposition patterns produced by incident photons in the close vicinity of the mitochondrial network modeled as a tube. Spherical shaped gold nanoparticles of 30 nm diameter were placed in a micrometric (10 x 10 x 10 mu m(3)) water phantom containing a tube of 300 nm diameter and 5 mu m length. The tube represented a mitochondrial fragment and nanoparticles were distributed in the water phantom outside the tube. Photons of 120 keV were simulated using the Geant4 Livermore processes and the Geant4-DNA electron processes to account for secondary electrons collisions. The Livermore processes took into account the Auger cascade inside the gold material. A data mining algorithm was then used to analyze the energy deposition clusters inside the water phantom and the tube. A comparison was made between the results obtained for a uniform distribution of nanoparticles and a vesicle distribution model. The results including energy deposition clusters are also compared to dose enhancement ratios.|
|Subject:||Nanopartículas de ouro|
Monte Carlo, Método de
Dano ao DNA
Monte Carlo method
|Appears in Collections:||IFGW - Artigos e Outros Documentos|
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