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|Title:||Fluoroquinolones in hospital wastewater: analytical method, occurrence, treatment with ozone and residual antimicrobial activity evaluation|
Porto, Rafael S.
dos Santos, Sabrina G.
|Abstract:||Fluoroquinolones antimicrobials are partially excreted in natura after administration. Their occurrence was investigated in hospital raw sewage (HRS) and treated wastewater (TW) using an online solid phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry method (SPE-UHPLC-MS/MS). The analytical curves ranged from 0.25 to 46 ng mL(-1) and the matrix effect, assessed for marbofloxacin and lomefloxacin, ranged from -63 to +1%. All HRS samples contained ciprofloxacin (1-34 ng mL(-1)) and ofloxacin (0.9-27 ng mL(-1)), while norfloxacin was detected in 17% of the samples (0.8-4.4 ng mL(-1)). Only ciprofloxacin (0.5-5.6 ng mL(-1)) was detected in TW samples. The antimicrobial activity of the HRS samples for E. coli was higher than a ciprofloxacin solution of 1 mg L-1, due to the presence of other antimicrobial agents. Ozonation (10 mg O-3 L-1 min(-1); 10 min) degraded up to 84% of the fluoroquinolones and removed the antimicrobial activity of HRS samples|
|Editor:||Sociedade Brasileira de Química|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
FEC - Artigos e Outros Documentos
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