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|Title:||Deracemization of sec-Alcohols through sequential application of C. albicans and ketoreductases|
|Author:||Nasario, Fabio D.|
Moran, Paulo J. S.
Rodrigues, Jose Augusto R.
|Abstract:||A biocatalytic cascade process was developed using immobilized cells of the wild type yeast Candida albicans CCT 0776 in calcium alginate beads and a commercially available ketoreductase. The aim was to promote deracemization by stereoinversion of (+/-)-1-arylethanols in high substrate concentration (above 100 mmol L-1) to prepare the (R)-enantiomers of the alcohols (90-99%). with a high enantiomeric excess (83-99%) after 2 to 19 h. The (R)-1-(3-methoxyphenyl)ethanol, with 70% yield and 91% ee, obtained after 5 h was used to prepare (S)-1-(3-methoxyphenyl)-ethylamine with 60% yield and 91% ee after two steps. a key intermediate in the synthesis of (S)-rivastigmine|
|Subject:||Resolução cinética oxidativa|
|Editor:||Sociedade Brasileira de Química|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
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