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Type: Artigo
Title: Deracemization of sec-Alcohols through sequential application of C. albicans and ketoreductases
Author: Nasario, Fabio D.
Moran, Paulo J. S.
Rodrigues, Jose Augusto R.
Abstract: A biocatalytic cascade process was developed using immobilized cells of the wild type yeast Candida albicans CCT 0776 in calcium alginate beads and a commercially available ketoreductase. The aim was to promote deracemization by stereoinversion of (+/-)-1-arylethanols in high substrate concentration (above 100 mmol L-1) to prepare the (R)-enantiomers of the alcohols (90-99%). with a high enantiomeric excess (83-99%) after 2 to 19 h. The (R)-1-(3-methoxyphenyl)ethanol, with 70% yield and 91% ee, obtained after 5 h was used to prepare (S)-1-(3-methoxyphenyl)-ethylamine with 60% yield and 91% ee after two steps. a key intermediate in the synthesis of (S)-rivastigmine
Subject: Resolução cinética oxidativa
Country: Brasil
Editor: Sociedade Brasileira de Química
Rights: Aberto
Identifier DOI: 10.21577/0103-5053.20180205
Date Issue: 2019
Appears in Collections:IQ - Artigos e Outros Documentos

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