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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampDella Coletta, Ricardo-
dc.typeArtigopt_BR
dc.titleA proposal to revise the histopathologic grading system of early oral tongue cancer incorporating tumor buddingpt_BR
dc.contributor.authorElseragy, Amr-
dc.contributor.authorSalo, Tuula-
dc.contributor.authorColetta, Ricardo D.-
dc.contributor.authorKowalski, Luiz P.-
dc.contributor.authorHaglund, Caj-
dc.contributor.authorNieminen, Pentti-
dc.contributor.authorMakitie, Antti A.-
dc.contributor.authorLeivo, Ilmo-
dc.contributor.authorAlmangush, Alhadi-
dc.subjectPrognósticopt_BR
dc.subject.otherlanguagePrognosispt_BR
dc.description.abstractThe World Health Organization (WHO) grading system has a low prognostic value for early-stage oral tongue squamous cell carcinoma; greater prognostic power has been shown with tumor budding analysis. In this study, we combined tumor budding analysis with histopathologic grading according to WHO 2017. In our proposal, a revised grade I tumor is defined as a well differentiated cohesive tumor; revised grade II as a moderately differentiated and/or slightly dissociated tumor; and revised grade III as a poorly differentiated and/or dissociated tumor. We evaluated the prognostic value of this proposed grading system in a multicenter cohort of 311 cases of early oral tongue squamous cell carcinoma. The proposed grading system showed significant prognostic value in multivariable analysis for disease-specific survival with a hazard ratio of 3.86 and a 95% confidence interval of 1.36-10.9 (P=0.001). For disease-free survival, the proposed grading system showed good predictive power in multivariable analysis (hazard ratio, 2.07; 95% confidence interval, 1.00-4.27; P=0.009). The conventional WHO grading system showed a low prognostic value for disease-specific survival and disease-free survival (P>0.05). In conclusion, the prognostic power of the WHO histopathologic grading improved significantly with incorporation of tumor budding. Our proposed grading system can be easily included in pathology reportspt_BR
dc.relation.ispartofAmerican journal of surgical pathologypt_BR
dc.relation.ispartofabbreviationAm. j. surg. Pathol.pt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.date.issued2019-
dc.date.monthofcirculationMaypt_BR
dc.language.isoengpt_BR
dc.description.volume43pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage703pt_BR
dc.description.lastpage709pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0147-5185pt_BR
dc.identifier.eissn1532-0979pt_BR
dc.identifier.doi10.1097/PAS.0000000000001241pt_BR
dc.identifier.urlhttps://journals.lww.com/ajsp/Fulltext/2019/05000/A_Proposal_to_Revise_the_Histopathologic_Grading.14.aspxpt_BR
dc.date.available2020-05-12T18:20:07Z-
dc.date.accessioned2020-05-12T18:20:07Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-05-12T18:20:07Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:16:20Z : No. of bitstreams: 1 000467716300014.pdf: 644958 bytes, checksum: 903b394f5fe04ebe8eeafcb25f0ae04c (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-12T18:20:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/340719-
dc.contributor.departmentDepartamento de Diagnóstico Oralpt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordOral tongue squamous cell carcinoma (OTSCC)pt_BR
dc.subject.keywordWHO histopathologic gradingpt_BR
dc.subject.keywordTumor buddingpt_BR
dc.identifier.source000467716300014pt_BR
dc.creator.orcid0000-0001-5285-3046pt_BR
dc.type.formArtigo originalpt_BR
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