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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampStelini, Rafael Fantelli-
dc.contributor.authorunicampCintra, Maria Letícia-
dc.typeArtigopt_BR
dc.titleEndoglin is highly expressed in human mast cellspt_BR
dc.contributor.authorBrum, Suellen Trentin-
dc.contributor.authorDemasi, Ana Paula-
dc.contributor.authorStelini, Rafael Fantelli-
dc.contributor.authorCintra, Maria Leticia-
dc.contributor.authorde Araujo, Vera Cavalcanti-
dc.contributor.authorSoares, Andresa Borges-
dc.subjectMastocitosept_BR
dc.subject.otherlanguageMastocytosispt_BR
dc.description.abstractEndoglin, known to be expressed in proliferating vessels, is of worth when evaluating microvessel density as a prognostic factor in many types of malignancies, including some subtypes of leukemia cells. In childhood acute lymphoblastic leukemia, endoglin is associated with adverse outcome. In bone marrow, endoglin identifies the repopulating hematopoietic stem cells. Mast cells are a component of normal tissue and play an important role in the regulation of several processes, including inflammation and neoplasia. The aim of this study was to evaluate the use of endoglin as a biological marker of mast cells compared with the gold standard stains. We studied 15 specimens of neurofibroma, 9 of mastocytosis, and 6 of fibrous scar tissue through immunohistochemistry (for endoglin and mast cell tryptase) and histochemical staining using toluidine blue. Quantitative analysis of the cells was performed by counting 5 hotspots. The validity of endoglin as a mast cell marker was assessed by intraclass correlation coefficient. The Kruskal-Wallis test was used to compare mast cell count for each marker. A strong endoglin expression was found in the cytoplasmic granules of mast cells within the 3 groups. Similar results were observed with mast cell tryptase as well as toluidine blue. The intraclass correlation coefficient revealed that endoglin is a highly reliable biomarker of mast cells when compared with mast cell tryptase and toluidine blue. In conclusion, endoglin may assist in the diagnosis and pathogenesis study of various processes associated with mast cells. An endoglin-neutralizing treatment for solid cancers and leukemia could also affect mastocytes and the immunologic systempt_BR
dc.relation.ispartofApplied immunohistochemistry & molecular morphologypt_BR
dc.relation.ispartofabbreviationAppl. immunohistochem. mol. morphol.pt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.date.issued2019-
dc.date.monthofcirculationSept.pt_BR
dc.language.isoengpt_BR
dc.description.volume27pt_BR
dc.description.issuenumber8pt_BR
dc.description.firstpage613pt_BR
dc.description.lastpage617pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1541-2016pt_BR
dc.identifier.eissn1533-4058pt_BR
dc.identifier.doi10.1097/PAI.0000000000000668pt_BR
dc.identifier.urlhttps://journals.lww.com/appliedimmunohist/Fulltext/2019/09000/Endoglin_is_Highly_Expressed_in_Human_Mast_Cells.8.aspxpt_BR
dc.date.available2020-05-12T18:04:05Z-
dc.date.accessioned2020-05-12T18:04:05Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-05-12T18:04:05Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:17:06Z : No. of bitstreams: 1 000487641500010.pdf: 277875 bytes, checksum: 902989c1b06f6546aeb66e67f36476d0 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-12T18:04:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/340713-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordEndoglinpt_BR
dc.subject.keywordMast cell tryptasept_BR
dc.subject.keywordToluidine bluept_BR
dc.subject.keywordNeurofibromapt_BR
dc.subject.keywordMastocytosispt_BR
dc.identifier.source000487641500010pt_BR
dc.creator.orcid0000-0003-0618-1693pt_BR
dc.creator.orcid0000-0001-7125-2238pt_BR
dc.type.formArtigo de pesquisapt_BR
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