Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/340562
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBombarda, Gabriela Fernanda-
dc.contributor.authorunicampRosalen, Pedro Luiz-
dc.contributor.authorunicampSilva, Diego Romário-
dc.contributor.authorunicampLazarini, Josy Goldoni-
dc.contributor.authorunicampFreires, Irlan de Almeida-
dc.contributor.authorunicampSardi, Janaina de Cassia Orlandi-
dc.typeArtigopt_BR
dc.titleBioactive molecule optimized for biofilm reduction related to childhood cariespt_BR
dc.contributor.authorBombarda, Gabriela F.-
dc.contributor.authorRosalen, Pedro L.-
dc.contributor.authorPaganini, Eder R.-
dc.contributor.authorGarcia, Mayara A. R.-
dc.contributor.authorSilva, Diego R.-
dc.contributor.authorLazarini, Josy G.-
dc.contributor.authorFreires, Irlan A.-
dc.contributor.authorRegasini, Luis O.-
dc.contributor.authorSardi, Janaina C. O.-
dc.subjectStreptococcus mutanspt_BR
dc.subjectToxicidadept_BR
dc.subject.otherlanguageStreptococcus mutanspt_BR
dc.subject.otherlanguageToxicitypt_BR
dc.description.abstractTo evaluate antimicrobial activity of a new nitrochalcone (NC-E08) against Candida albicans and Streptococcus mutans, and its toxicity. Materials & methods: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration/minimum fungicidal concentration (MFC) were determined against C. albicans and S. mutans, as well as antibiofilm potential and toxicity (human gingival fibroblast and Galleria mellonella). Infection and treatment were performed in G. mellonella. Results & conclusion: NC-E08 showed antimicrobial activity in C. albicans (MIC: 0.054 mM) and S. mutans (MIC: 0.013 mM); 10xMIC treatment reduced 4.0 log10 biofilms for both strains and there was a reduction in survival of mixed biofilms of C. albicans and S. mutans (6.0 and 4.0 log10, respectively). NC-E08 showed no cytotoxicity in human gingival fibroblast cells and G. mellonella. NC-E08 after larval infection protected them 90% (p<0.05). Thus, is a promising one for the prevention and treatment of S. mutans and C. albicans infections.pt_BR
dc.relation.ispartofFuture microbiologypt_BR
dc.relation.ispartofabbreviationFuture microbiol.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherFuture Medicinept_BR
dc.date.issued2019-
dc.date.monthofcirculationSept.pt_BR
dc.language.isoengpt_BR
dc.description.volume14pt_BR
dc.description.issuenumber14pt_BR
dc.description.firstpage1207pt_BR
dc.description.lastpage1220pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1746-0913pt_BR
dc.identifier.eissn1746-0921pt_BR
dc.identifier.doi10.2217/fmb-2019-0144pt_BR
dc.identifier.urlhttps://www.futuremedicine.com/doi/10.2217/fmb-2019-0144pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsordocumentnumber474335/2013; 474335/2013-5pt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2020-05-11T16:02:07Z-
dc.date.accessioned2020-05-11T16:02:07Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-05-11T16:02:07Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:17:24Z : No. of bitstreams: 1 000498059400062.pdf: 4453639 bytes, checksum: 8979fac2083f60e5d6a6f038bd712d35 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-11T16:02:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/340562-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordCandida albicanspt_BR
dc.subject.keywordGalleria mellonellapt_BR
dc.subject.keywordMixed biofilmpt_BR
dc.subject.keywordNitrochalconept_BR
dc.identifier.source000498059400062pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcidorcid.org/0000-0003-0812-4027pt_BR
dc.creator.orcidorcid.org/0000-0003-0081-5229pt_BR
dc.creator.orcidorcid.org/0000-0002-3498-8243pt_BR
dc.creator.orcidorcid.org/0000-0002-1079-6941pt_BR
dc.creator.orcidorcid.org/0000-0002-8500-2691pt_BR
dc.type.formArtigo de pesquisapt_BR
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