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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCampos, Brunno Machado de-
dc.typeArtigopt_BR
dc.titleCircadian phenotype impacts the brain's resting-state functional connectivity, attentional performance, and sleepinesspt_BR
dc.contributor.authorFacer-Childs, Elise R.-
dc.contributor.authorCampos, Brunno M.-
dc.contributor.authorMiddleton, Benita-
dc.contributor.authorSkene, Debra J.-
dc.contributor.authorBagshaw, Andrew P.-
dc.subjectRede de modo padrãopt_BR
dc.subject.otherlanguageDefault mode networkpt_BR
dc.description.abstractIntroduction Functional connectivity (FC) of the human brain's intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC. Study Objectives The aim of this study was to investigate resting-state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day. Methods Thirty-eight healthy individuals (14 male, 22.7 4.2 years) categorized as Early (n = 16) or Late (n = 22) using the Munich ChronoType Questionnaire took part. Following a 2-week baseline of actigraphy coupled with saliva samples for melatonin and cortisol rhythms, participants underwent testing at 14:00 hours, 20:00 hours, and 08:00 hours the following morning. Testing consisted of resting-state functional magnetic resonance imaging (fMRI), a structural T1 scan, attentional cognitive performance tasks, and self-reported daytime sleepiness. Seed-based FC analysis from the medial prefrontal and posterior cingulate cortices of the DMN was performed, compared between groups and linked with behavioral data. Results Fundamental differences in the DMN were observed between Early and Late circadian phenotypes. Resting-state FC of the DMN predicted individual differences in attention and subjective ratings of sleepiness. Conclusion Differences in FC of the DMN may underlie the compromised attentional performance and increased sleepiness commonly associated with Late types when they conform to a societally constrained day that does not match their intrinsic circadian phenotypept_BR
dc.relation.ispartofSleeppt_BR
dc.publisher.cityCary, NCapt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherOxford University Presspt_BR
dc.date.issued2019-
dc.date.monthofcirculationMaypt_BR
dc.language.isoengpt_BR
dc.description.volume42pt_BR
dc.description.issuenumber5pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn1550-9109pt_BR
dc.identifier.doi10.1093/sleep/zsz033pt_BR
dc.identifier.urlhttps://academic.oup.com/sleep/article/42/5/zsz033/5316210pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2013/07559-3pt_BR
dc.date.available2020-05-08T20:16:11Z-
dc.date.accessioned2020-05-08T20:16:11Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-05-08T20:16:11Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:16:27Z : No. of bitstreams: 1 000470663100011.pdf: 25865552 bytes, checksum: 0c14b8ba05fa44b543653c043037d29b (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-08T20:16:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/340501-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.subject.keywordResting-state functional magnetic resonance imaging (fMRI)pt_BR
dc.subject.keywordCircadian phenotypept_BR
dc.subject.keywordSleeppt_BR
dc.subject.keywordAttentional performancept_BR
dc.subject.keywordSleepinesspt_BR
dc.subject.keywordCircadian rhythmspt_BR
dc.identifier.source000470663100011pt_BR
dc.creator.orcid0000-0003-1261-8257pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleidzsz033pt_BR
dc.description.sponsorNoteThis work was supported by funding from the Biotechnology and Biological Sciences Research Council (BBSRC, BB/J014532/1) and the Engineering and Physical Sciences Research Council (EPSRC, EP/J002909/1) as well as theFundação de Amparo à Pesquisa do Estado de São Paulo (#2013/07559-3). E.R.F-C. was supported by an Institutional Strategic Support Fund Accelerator Fellowship through the Wellcome Trust (Wellcome, 204846/Z/16/Z)pt_BR
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