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|Title:||Bioguided identification of antimicrobial compounds from Chrysopogon zizaniodes (L.) Roberty root essential oil|
|Author:||Ramirez-Rueda, Roman Y.|
Salvador, Marcos J.
|Abstract:||To determine the group of compounds from Chrysopogon zizaniodes root essential oil that have antimicrobial activity. Materials & methods: Thin-layer chromatography coupled to direct bioautography was used to determinate the fraction(s) having antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF). Through GC-MS identification, the fractions with the greatest similarity to the active thin-layer chromatography fraction were used to determinate the MIC. Results: The subfraction 8 from column chromatography was responsible for the best MIC for MRSA (62.5 mu g/ml) and VREF (125 mu g/ml). Five compounds possibly responsible for antimicrobial activity were preliminary identified. Conclusion: We suggest that Cedr-8-en-13-ol, could be the more relevant compound involved in the antimicrobial activity in this study.|
|Appears in Collections:||IB - Artigos e Outros Documentos|
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