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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampGandra, Paulo Guimarães-
dc.typeArtigopt_BR
dc.titleVoluntary wheel running: patterns and physiological effects in micept_BR
dc.contributor.authorManzanares, G.-
dc.contributor.authorBrito-da-Silva, G.-
dc.contributor.authorGandra, P. G.-
dc.subjectMúsculo esqueléticopt_BR
dc.subjectFisiopatologiapt_BR
dc.subject.otherlanguageSkeletal musclept_BR
dc.subject.otherlanguagePhysiology, Pathologicalpt_BR
dc.description.abstractExercise can prevent and improve the pathophysiology of diseases and promote healthy aging. Thus, understanding the mechanisms that regulate the beneficial effects of exercise may lead to the development of new strategies to enhance quality of life and to counteract chronic diseases. Voluntary wheel running is an interesting model to study the effects of exercise in mice. Compared to forced treadmill exercise, voluntary wheel running presents several advantages such as: 1) running pattern is similar to natural running behavior of mice; 2) it is performed under non-stressed conditions, according to the rhythmicity of the animal; 3) it does not require direct interference from the researcher, and can be easily applied in long-term studies. Mice run spontaneously when given access to running wheels, for a total distance of similar to 4 to 20 km per day and a total activity time of similar to 3 to 7 hours a day. Hence, voluntary wheel running can result in robust endurance-like adaptation in skeletal and cardiac muscles and protect from sarcopenia. However, due to the lack of control over exercise parameters in voluntary exercise models, it is important for the researcher to understand the patterns and variability of wheel running in mice, as well as the factors that can affect voluntary running activity. Overall, voluntary wheel running in mice is a very interesting approach to study the chronic adaptation to exercise, analyze the effects of exercise, and test exercise capacity in different experimental modelspt_BR
dc.relation.ispartofBrazilian journal of medical and biological researchpt_BR
dc.relation.ispartofabbreviationBraz. j. med. biol. res.pt_BR
dc.publisher.cityRibeirão Preto, SPpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherAssociação Brasileira de Divulgação Científicapt_BR
dc.date.issued2019-
dc.language.isoengpt_BR
dc.description.volume52pt_BR
dc.description.issuenumber1pt_BR
dc.rightsAbertopt_BR
dc.sourceSCiELOpt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.eissn1414-431Xpt_BR
dc.identifier.doi10.1590/1414-431X20187830pt_BR
dc.identifier.urlhttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100301pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsordocumentnumber423317/2016-4pt_BR
dc.date.available2020-05-08T17:32:06Z-
dc.date.accessioned2020-05-08T17:32:06Z-
dc.description.provenanceSubmitted by Cintia Oliveira de Moura (cintiaom@unicamp.br) on 2020-05-08T17:32:06Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:16:01Z : No. of bitstreams: 1 S0100-879X2019000100301.pdf: 704995 bytes, checksum: 6e08c66c453bff6d701d6b7c9fbdd0ec (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-08T17:32:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/340450-
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordVoluntary wheel runningpt_BR
dc.subject.keywordEndurance adaptationpt_BR
dc.identifier.sourceS0100-879X2019000100301pt_BR
dc.creator.orcid0000-0002-4945-8288pt_BR
dc.type.formArtigo de revisãopt_BR
dc.identifier.articleide7830pt_BR
dc.description.sponsorNoteConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)National Council for Scientific and Technological Development (CNPq) [423317/2016-4]; FAEPEX Undergraduate Research Fellowship (Fundo de Apoio ao Ensino a Pesquisa e Extensao da Unicamp) [2818/17]pt_BR
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