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Type: Artigo
Title: Homeostatic model assessment of adiponectin (HOMA-Adiponectin) as a surrogate measure of insulin resistance in adolescents: comparison with the hyperglycaemic clamp and homeostatic model assessment of insulin resistance
Author: da Silva, Cleliani de Cassia
Zambon, Mariana Porto
Junqueira Vasques, Ana Carolina
Camilo, Daniella Fernandes
De Bernardi Rodrigues, Ana Maria
de Goes Monteiro Antonio, Maria Angela Reis
Damaso, Ana Raimunda
Tufik, Sergio
de Mello, Marco Tulio
da Silveira Campos, Raquel Munhoz
Geloneze, Bruno
Biill Alves, Arnandra Nichaela
Sitta, Bruna Dyane
Caturani de Araujo, Camila Inajara
Nogueira, Fabiana Lopes
Barreiro-Ribeiro, Francieli
Pareja, Jose Carlos
dos Santos, Leandra Giorgetti
Oliveira, Mariana da Silva
Ferrari, Mariana Pontes
Mello, Mayra
Rodrigues, Patricia Brito
Lara Cassani, Roberta Soares
Rodrigues de Meira, Stela Caroline
Rugolo, Vanessa Cristine
Abstract: Background Studies on adults have reported inverse association between the homeostatic model assessment (HOMA) of adiponectin (HOMA-Adiponectin) and the insulin resistance assessed by the glucose clamp technique. To our knowledge, in the pediatric population this association has not been previously investigated. Objectives To evaluate the association between the HOMA-Adiponectin and the insulin resistance assessed by the glucose clamp technique in adolescents, and to compare the accuracy of HOMA-Adiponectin and HOMA-insulin resistance (HOMA-IR) for identifying insulin resistance. Methods This was a cross-sectional study of 56 adolescents (aged 1018 years). Insulin resistance was assessed using the HOMA-IR, HOMA-Adiponectin and the hyperglycaemic clamp technique. The clamp-derived insulin sensitivity index, HOMA-Adiponectin, and HOMA-IR were log-transformed to get closer to a normal distribution before analysis. Results In the multivariable linear regression analysis controlling for sex and Tanner stage, HOMA-Adiponectin was inversely associated with the clamp-derived insulin sensitivity index (unstandardized coefficient [B] = -0.441; P < 0.001). After additional adjustment for waist circumference-to-height ratio, this association remained significant (B = -0.349; P = < 0.001). Similar results were observed when HOMA-IR replaced HOMA-Adiponectin in the model (B = -1.049 and B = -0.968 after additional adjustment for waist circumference-to-height ratio); all P < 0.001. The area under the receiver operating characteristic curve for predicting insulin resistance was 0.712 (P = 0.02) for HOMA-Adiponectin and 0.859 (P < 0.0001) HOMA-IR. Conclusions The HOMA-Adiponectin was independently associated with insulin resistance and exhibited a good discriminatory power for predicting it. However, it did not show superiority over HOMA-IR in the diagnostic accuracy
Subject: Adiponectina
Resistência à insulina
Country: Estados Unidos
Editor: Public Library of Science
Rights: Aberto
Identifier DOI: 10.1371/journal.pone.0214081
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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