Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/340403
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFerrari, Állan Jhonathan Ramos-
dc.contributor.authorunicampGozzo, Fábio Cesar-
dc.contributor.authorunicampMartínez, Leandro-
dc.typeArtigopt_BR
dc.titleTopoLink: evaluation of structural models using chemical crosslinking distance constraintspt_BR
dc.contributor.authorFerrari, Allan J. R.-
dc.contributor.authorClasen, Milan A.-
dc.contributor.authorKurt, Louise-
dc.contributor.authorCarvalho, Paulo C.-
dc.contributor.authorGozzo, Fabio C.-
dc.subjectProteínas - Ligações cruzadaspt_BR
dc.subject.otherlanguageProteins - Crosslinkingpt_BR
dc.description.abstractA software was developed to evaluate structural models using chemical crosslinking experiments. The user provides the types of linkers used and their reactivity, and the observed crosslinks and dead-ends. The software computes the minimum length of a physically inspired linker that connects the reactive atoms of interest, and reports the consistency of each distance with the experimental observation. Statistics on model consistency with the links are provided. Tools to evaluate the correlation of crosslinks in ensembles of models were developed. TopoLink was used to evaluate the potential crosslinks of all structures of the CATH database. The number of crosslinks expected as a function of protein size and linker length can be used as guide for experimental designpt_BR
dc.relation.ispartofBioinformaticspt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherOxford University Presspt_BR
dc.date.issued2019-
dc.date.monthofcirculationSep.pt_BR
dc.language.isoengpt_BR
dc.description.volume35pt_BR
dc.description.issuenumber17pt_BR
dc.description.firstpage3169pt_BR
dc.description.lastpage3170pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1367-4803pt_BR
dc.identifier.eissn1460-2059pt_BR
dc.identifier.doi10.1093/bioinformatics/btz014pt_BR
dc.identifier.urlhttps://academic.oup.com/bioinformatics/article-abstract/35/17/3169/5284905pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2010/16947-9; 2013/05475-7; 2013/08293-7; 2016/13195-2; 2018/14274-9pt_BR
dc.date.available2020-05-08T11:41:48Z-
dc.date.accessioned2020-05-08T11:41:48Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-05-08T11:41:48Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:17:06Z : No. of bitstreams: 1 000487323400042.pdf: 2124702 bytes, checksum: 3078e1165639de27c69170ed69362306 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-08T11:41:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/340403-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Química Orgânicapt_BR
dc.contributor.departmentDepartamento de Físico-Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.contributor.unidadeInstituto de Químicapt_BR
dc.identifier.source000487323400042pt_BR
dc.creator.orcid0000-0002-9199-2257pt_BR
dc.creator.orcid0000-0002-5270-4427pt_BR
dc.creator.orcid0000-0002-6857-1884pt_BR
dc.type.formArtigopt_BR
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