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Type: Artigo
Title: TopoLink: evaluation of structural models using chemical crosslinking distance constraints
Author: Ferrari, Allan J. R.
Clasen, Milan A.
Kurt, Louise
Carvalho, Paulo C.
Gozzo, Fabio C.
Abstract: A software was developed to evaluate structural models using chemical crosslinking experiments. The user provides the types of linkers used and their reactivity, and the observed crosslinks and dead-ends. The software computes the minimum length of a physically inspired linker that connects the reactive atoms of interest, and reports the consistency of each distance with the experimental observation. Statistics on model consistency with the links are provided. Tools to evaluate the correlation of crosslinks in ensembles of models were developed. TopoLink was used to evaluate the potential crosslinks of all structures of the CATH database. The number of crosslinks expected as a function of protein size and linker length can be used as guide for experimental design
Subject: Proteínas - Ligações cruzadas
Country: Reino Unido
Editor: Oxford University Press
Rights: Fechado
Identifier DOI: 10.1093/bioinformatics/btz014
Date Issue: 2019
Appears in Collections:IQ - Artigos e Outros Documentos

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