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Type: Artigo
Title: Scintigraphic evaluation of the impact of pneumoperitoneum on renal blood flow: a rabbit model
Author: de Freitas Junior, Segirson
Bustorff-Silva, Joaquim Murray
Ramos, Celso Dario
Brunetto, Sergio Querino
Marques da Costa, Ana Paula
Antunes, Amanda Ginani
Ventura Biavatti, Belisa Brunow
Franchi Junior, Gilberto Carlos
Moreira, Marcos Mello
Guimaraes Felix, Paula Cristina
Miranda, Marcio Lopes
Abstract: Increased intra-abdominal pressure resulting from pneumoperitoneum can cause renal physiological changes, such as oliguria and anuria, in mammals. Although videolaparoscopic operations are common, the occurrence of renal lesions due to these procedures has not been precisely documented in the literature. The aim of this study was to evaluate the impact of pneumoperitoneum on renal blood flow using renal scintigraphy in a rabbit model. Methods: Six New Zealand male rabbits weighing 3 kg, previously anesthetized, were mechanically ventilated and underwent pneumoperitoneum. Each animal served as its own control and was analyzed in two different moments: [99mTc] diethylenetriaminepentaacetic acid (DTPA) renal blood flow evaluation in baseline conditions (T0) and 30 minutes after installation of 15 mmHg-pneumoperitoneum (T1). The animals were monitored throughout the study by capnography, oximetry, and arterial pressure median, and were euthanized at the end of the experiment. Results: The quantitative analysis of the scintigraphic images of renal uptake of the radiopharmaceutical evidence reduced renal arterial blood flow during pneumoperitoneum. Compared with baseline conditions, all animals presented a reduction of renal blood flow varying from 16% to 82%, with mean [+/- standard deviation] of 53% [+/- 24%]. Conclusions: Pneumoperitoneum induces a significant reduction of the renal blood flow, as determined in this experimental method in rabbits and dynamic renal scintigraphy with [99mTc] DTPA is an adequate method to investigate this event in the experimental setting
Subject: Pneumoperitônio
Country: Estados Unidos
Editor: Mary Ann Liebert
Rights: Fechado
Identifier DOI: 10.1089/lap.2019.0194
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos
Cipoi - Artigos e Outros Documentos

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