Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/340158
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSerpe, Luciano-
dc.contributor.authorunicampMuniz, Bruno Vilela-
dc.contributor.authorunicampSantos, Cleiton Pita dos-
dc.contributor.authorunicampVolpato, Maria Cristina-
dc.contributor.authorunicampGroppo, Francisco Carlos-
dc.contributor.authorunicampFranz-Montan, Michelle-
dc.typeArtigopt_BR
dc.titleFull-thickness intraoral mucosa barrier models for In vitro drug-permeation studies using microneedlespt_BR
dc.contributor.authorSerpe, Luciano-
dc.contributor.authorMuniz, Bruno Vilela-
dc.contributor.authordos Santos, Cleiton Pita-
dc.contributor.authorda Silva, Camila Batista-
dc.contributor.authorVolpato, Maria Cristina-
dc.contributor.authorGroppo, Francisco Carlos-
dc.contributor.authorVianna Lopez, Renata Fonseca-
dc.contributor.authorFranz-Montan, Michelle-
dc.subjectPermeabilidadept_BR
dc.subject.otherlanguagePermeabilitypt_BR
dc.description.abstractThe use of permeation enhancers such as microneedles (MNs) to increase drug penetration across intraoral mucosa has increased in recent years. Permeation studies, commonly performed using vertical diffusion cells, are a well-established way to preview formulations and enhance their performance during the development stage. However, to our knowledge, the existing intraoral mucosa barrier models do not permit permeation using MN-pretreated mucosa due to their insufficient thickness. Therefore, the objective of this study was to develop a barrier model using thick palate tissues to perform in vitro permeation studies, with physical enhancement of the permeability of intraoral mucosa by pretreatment with MNs. The adapted Franz-type cells used in the permeation experiments were validated (cell dimensions and volume, sealing effectiveness, stirring and dissolution efficiency, temperature control, and establishment of uniaxial flux). Commercially available MNs were used in the palatal mucosa. Optical images of the mucosa were acquired to analyze the microperforations created. In vitro permeation studies were conducted with the MN-pretreated mucosa. This work presents a new in vitro method for the evaluation of MNs as permeation enhancers, with the aim of improving the absorption of drug formulations topically applied within the oral cavitypt_BR
dc.relation.ispartofJournal of pharmaceutical sciencespt_BR
dc.relation.ispartofabbreviationJ. pharm. sci.pt_BR
dc.publisher.cityNew York, NYpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.date.monthofcirculationMaypt_BR
dc.language.isoengpt_BR
dc.description.volume108pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage1756pt_BR
dc.description.lastpage1764pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0022-3549pt_BR
dc.identifier.eissn1520-6017pt_BR
dc.identifier.doi10.1016/j.xphs.2018.12.004pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0022354918307998pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumber2011/18113-0; 2012/06974-4; 2012/02492-5pt_BR
dc.date.available2020-05-05T17:42:20Z-
dc.date.accessioned2020-05-05T17:42:20Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-05-05T17:42:20Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-11-11T13:13:38Z : No. of bitstreams: 1 000477746900011.pdf: 2458030 bytes, checksum: 9198988a6172882f60e7616f56ef9334 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-05T17:42:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2018en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/340158-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordIntraoral mucosapt_BR
dc.subject.keywordMucosal drug deliverypt_BR
dc.subject.keywordIn vitro modelspt_BR
dc.subject.keywordDiffusionpt_BR
dc.subject.keywordMicroneedlespt_BR
dc.subject.keywordLocal anestheticspt_BR
dc.identifier.source000477746900011pt_BR
dc.creator.orcid0000-0001-6701-9361pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-1459-7050pt_BR
dc.creator.orcid0000-0002-8513-773Xpt_BR
dc.creator.orcid0000-0003-0760-1389pt_BR
dc.type.formArtigo de pesquisapt_BR
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