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Type: Artigo
Title: Full-thickness intraoral mucosa barrier models for In vitro drug-permeation studies using microneedles
Author: Serpe, Luciano
Muniz, Bruno Vilela
dos Santos, Cleiton Pita
da Silva, Camila Batista
Volpato, Maria Cristina
Groppo, Francisco Carlos
Vianna Lopez, Renata Fonseca
Franz-Montan, Michelle
Abstract: The use of permeation enhancers such as microneedles (MNs) to increase drug penetration across intraoral mucosa has increased in recent years. Permeation studies, commonly performed using vertical diffusion cells, are a well-established way to preview formulations and enhance their performance during the development stage. However, to our knowledge, the existing intraoral mucosa barrier models do not permit permeation using MN-pretreated mucosa due to their insufficient thickness. Therefore, the objective of this study was to develop a barrier model using thick palate tissues to perform in vitro permeation studies, with physical enhancement of the permeability of intraoral mucosa by pretreatment with MNs. The adapted Franz-type cells used in the permeation experiments were validated (cell dimensions and volume, sealing effectiveness, stirring and dissolution efficiency, temperature control, and establishment of uniaxial flux). Commercially available MNs were used in the palatal mucosa. Optical images of the mucosa were acquired to analyze the microperforations created. In vitro permeation studies were conducted with the MN-pretreated mucosa. This work presents a new in vitro method for the evaluation of MNs as permeation enhancers, with the aim of improving the absorption of drug formulations topically applied within the oral cavity
Subject: Permeabilidade
Country: Estados Unidos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.xphs.2018.12.004
Date Issue: 2019
Appears in Collections:FOP - Artigos e Outros Documentos

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