Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/340102
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBataglioli, Rogério Aparecido-
dc.contributor.authorunicampTaketa, Thiago Bezerra-
dc.contributor.authorunicampRocha Neto, João Batista Maia-
dc.contributor.authorunicampLopes, Laise Maia-
dc.contributor.authorunicampBeppu, Marisa Masumi-
dc.typeArtigopt_BR
dc.titleAnalysis of pH and salt concentration on structural and model-drug delivery properties of polysaccharide-based multilayered filmspt_BR
dc.contributor.authorBataglioli, R. A.-
dc.contributor.authorTaketa, T. B.-
dc.contributor.authorRocha Neto, J. B. M.-
dc.contributor.authorLopes, L. M.-
dc.contributor.authorCosta, C. A. R.-
dc.contributor.authorBeppu, M. M.-
dc.subjectPolieletrólitospt_BR
dc.subject.otherlanguagePolyelectrolytespt_BR
dc.description.abstractThis paper explores the influence of pH and ionic strength of polyelectrolyte solutions as a simple and chemically amenable strategy for tuning the structure and drug delivery properties of polyelectrolyte multilayers produced via layer-by-layer technique. Carboxymethylcellulose/chitosan films were buildup under different pH (4.0 and 6.0) and salt concentrations (0 or 0.2 M NaCl) conditions. Systematic data analyses using Design of Experiments indicate that high ionic strength favors the formation of thinner and rougher films. Higher pH led to the formation of thinner and rougher films, attributed to the substantial decrease in the degree of ionization of carboxymethylcellulose and the random coil conformation of chitosan at the outermost layer, respectively. The random coiled conformation of chitosan near to neutral pH also seems to be the major factor to increase the surface film roughness under wet conditions. Drug delivery tests performed with Rose Bengal (model drug) indicate a predominant non-Fickian release mechanism for most of the buildup conditions tested. Densely packed multilayered films obtained at pH 6.0 and 0.2 M NaCl resulted in a faster, Fickian release mechanism, with minimal changes in surface morphology under wet conditions. The total amount of drug released shows a significative influence of only the polyelectrolyte solution pH, associated with the higher amount of free amino groups of chitosan at the film surface at higher pH conditions. These findings shed light on a strategy to develop functional coatings with tailored structural and drug delivery properties by simply controlling film depositions conditionspt_BR
dc.relation.ispartofThin solid films: international journal on the science and technology of condensed matter filmspt_BR
dc.relation.ispartofabbreviationThin solid filmspt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryPaíses Baixospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.date.monthofcirculationSept.pt_BR
dc.language.isoengpt_BR
dc.description.volume685pt_BR
dc.description.firstpage312pt_BR
dc.description.lastpage320pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0040-6090pt_BR
dc.identifier.eissn1879-2731pt_BR
dc.identifier.doi10.1016/j.tsf.2019.06.039pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0040609019304080pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumbernão tempt_BR
dc.description.sponsordocumentnumber2013/05135-1; 2016/10193-9; 2016/19976-6pt_BR
dc.date.available2020-05-05T12:00:52Z-
dc.date.accessioned2020-05-05T12:00:52Z-
dc.description.provenanceSubmitted by Mariana Aparecida Azevedo (mary1@unicamp.br) on 2020-05-05T12:00:52Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-08-27T19:16:41Z : No. of bitstreams: 1 000476884100042.pdf: 2169632 bytes, checksum: 405d56c44a5bbdd21a0a6dd19c1a7364 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-05-05T12:00:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/340102-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Engenharia de Materiais e de Bioprocessospt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.subject.keywordLayer-by-layerpt_BR
dc.subject.keywordDrug deliverypt_BR
dc.subject.keywordRose Bengalpt_BR
dc.identifier.source000476884100042pt_BR
dc.creator.orcid0000-0003-4987-1168pt_BR
dc.creator.orcid0000-0003-4861-1006pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-4640-7397pt_BR
dc.creator.orcid0000-0001-6519-6970pt_BR
dc.type.formArtigopt_BR
Appears in Collections:FEQ - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
000476884100042.pdf2.12 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.