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Type: Artigo
Title: Prevalence of oropharyngeal dysphagia in hereditary spastic paraplegias
Title Alternative: Prevalência de disfagia orofaríngea nas paraparesias espásticas hereditárias
Author: Jacinto-Scudeiro, Lais Alves
Machado, Gustavo Dariva
Ayres, Annelise
Burguez, Daniela
Polese-Bonatto, Marcia
Gonzalez-Salazar, Carelis
Siebert, Marina
Franca Junior, Marcondes Cavalcante
Olchik, Maira Rozenfeld
Morales Saute, Jonas Alex
Abstract: Hereditary spastic paraplegias (HSP) are a group of genetic diseases characterized by lower limb spasticity with or without additional neurological features. Swallowing dysfunction is poorly studied in HSP and its presence can lead to significant respiratory and nutritional complications. Objectives: The aim of this study was to evaluate the frequency and clinical characteristics of dysphagia in different types of HSP. Methods: A two-center cross-sectional prevalence study was performed. Genetically confirmed HSP patients were evaluated using the Northwestern Dysphagia Patient Check Sheet and the Functional Oral Intake Scale. In addition, self-perception of dysphagia was assessed by the Eat Assessment Tool-10 and the Swallowing Disturbance Questionnaire. Results: Thirty-six patients with spastic paraplegia type 4 (SPG4), five with SPG11, four with SPG5, four with cerebrotendinous xanthomatosis (CTX), three with SPG7, and two with SPG3A were evaluated. Mild to moderate oropharyngeal dysphagia was present in 3/5 (60%) of SPG11 and 2/4 (50%) of CTX patients. A single SPG4 (2%) and a single SPG7 (33%) patient had mild oropharyngeal dysphagia. All other evaluated patients presented with normal or functional swallowing. Conclusions: Clinically significant oropharyngeal dysphagia was only present in complicated forms of HSP. Patients with SPG11 and CTX had the highest risks for dysphagia,suggesting that surveillance of swallowing function should be part of the management of patients with these disorders
metadata.dc.description.abstractalternative: As paraparesias espásticas hereditárias (PEH) são um grupo de doenças genéticas caracterizado por espasticidade dos membros inferiores com ou sem características neurológicas adicionais. A disfunção da deglutição é pouco estudada nas PEH e sua presença pode levar a complicações respiratórias e nutricionais significativas
Subject: Paraplegia espástica hereditária
Transtornos de deglutição
Country: Brasil
Editor: Associação Arquivos de Neuro-Psiquiatria
Rights: Aberto
Identifier DOI: 10.1590/0004-282X20190180
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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