Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/339426
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampBóbbo, Vanessa Cristina Dias-
dc.contributor.authorunicampJara, Carlos Jorge Poblete-
dc.contributor.authorunicampMendes, Natália Ferreira-
dc.contributor.authorunicampMorari, Joseane-
dc.contributor.authorunicampVelloso, Licio Augusto-
dc.contributor.authorunicampAraujo, Eliana Pereira de-
dc.typeArtigopt_BR
dc.titleInterleukin-6 expression by hypothalamic microglia in multiple inflammatory contexts: a systematic reviewpt_BR
dc.contributor.authorBobbo, Vanessa C. D.-
dc.contributor.authorJara, Carlos P.-
dc.contributor.authorMendes, Natalia F.-
dc.contributor.authorMorari, Joseane-
dc.contributor.authorVelloso, Licio A.-
dc.contributor.authorAraujo, Eliana P.-
dc.subjectInterleucina-6pt_BR
dc.subject.otherlanguageInterleukin-6pt_BR
dc.description.abstractInterleukin-6 (IL-6) is a unique cytokine that can play both pro- and anti-inflammatory roles depending on the anatomical site and conditions under which it has been induced. Specific neurons of the hypothalamus provide important signals to control food intake and energy expenditure. In individuals with obesity, a microglia-dependent inflammatory response damages the neural circuits responsible for maintaining whole-body energy homeostasis, resulting in a positive energy balance. However, little is known about the role of IL-6 in the regulation of hypothalamic microglia. In this systematic review, we asked what types of conditions and stimuli could modulate microglial IL-6 expression in murine model. We searched the PubMed and Web of Science databases and analyzed 13 articles that evaluated diverse contexts and study models focused on IL-6 expression and microglia activation, including the effects of stress, hypoxia, infection, neonatal overfeeding and nicotine exposure, lipopolysaccharide stimulus, hormones, exercise protocols, and aging. The results presented in this review emphasized the role of injury-like stimuli, under which IL-6 acts as a proinflammatory cytokine, concomitant with marked microglial activation, which drive hypothalamic neuroinflammation. Emerging evidence indicates an important correlation of basal IL-6 levels and microglial function with the maintenance of hypothalamic homeostasis. Advances in our understanding of these different contexts will lead to the development of more specific pharmacological approaches for the management of acute and chronic conditions, like obesity and metabolic diseases, without disturbing the homeostatic functions of IL-6 and microglia in the hypothalamus.pt_BR
dc.relation.ispartofBiomed research internationalpt_BR
dc.relation.ispartofabbreviationBiomed res. int.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherHindawipt_BR
dc.date.issued2019-
dc.date.monthofcirculationAug.pt_BR
dc.language.isoengpt_BR
dc.description.volume2019pt_BR
dc.rightsAbertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn2314-6133pt_BR
dc.identifier.eissn2314-6141pt_BR
dc.identifier.doi10.1155/2019/1365210pt_BR
dc.identifier.urlhttps://www.hindawi.com/journals/bmri/2019/1365210/pt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.description.sponsordocumentnumber2013/07607-8pt_BR
dc.date.available2020-04-22T19:21:16Z-
dc.date.accessioned2020-04-22T19:21:16Z-
dc.description.provenanceSubmitted by Bruna Maria Campos da Cunha (bcampos@unicamp.br) on 2020-04-22T19:21:16Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-30T19:34:51Z : No. of bitstreams: 1 000484704800001.pdf: 2307546 bytes, checksum: 3e5f6dc387db14d1273f8a6a9d25b845 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-04-22T19:21:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/339426-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Enfermagempt_BR
dc.subject.keywordHypothalamic microgliapt_BR
dc.subject.keywordInflammatory contextspt_BR
dc.identifier.source000484704800001pt_BR
dc.creator.orcidorcid.org/0000-0003-2941-2386pt_BR
dc.creator.orcidorcid.org/0000-0001-5444-721Xpt_BR
dc.creator.orcidorcid.org/0000-0001-9032-1411pt_BR
dc.creator.orcidorcid.org/0000-0002-0728-4283pt_BR
dc.creator.orcidorcid.org/0000-0002-4806-7218pt_BR
dc.creator.orcidorcid.org/0000-0002-7539-8477pt_BR
dc.type.formArtigo de revisãopt_BR
dc.identifier.articleid1365210pt_BR
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