Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/339424
Type: Artigo
Title: Metabolomics applied to maternal and perinatal health: a review of new frontiers with a translation potential
Author: Souza, Renato Teixeira
Mayrink, Ussara
Leite, Debora Farias
Costa, Maria Laura
Calderon, Iracema Mattos
Rocha Filho, Edilberto Alves
Vettorazzi, Janete
Feitosa, Francisco Edson
Cecatti, Jose Guilherme
Baker, Philip N.
Kenny, Louise
Sulek, Karolina
Parpinelli, Mary A.
Franchini, Kleber G.
Melo, Elias Jr.
Anacleto, Danilo
Cassettari, Bianca F.
Vernini, Joice
Pfitscher, Lucia
Lucena, Daisy
Abstract: The prediction or early diagnosis of maternal complications is challenging mostly because the main conditions, such as preeclampsia, preterm birth, fetal growth restriction, and gestational diabetes mellitus, are complex syndromes with multiple underlying mechanisms related to their occurrence. Limited advances in maternal and perinatal health in recent decades with respect to preventing these disorders have led to new approaches, and "omics" sciences have emerged as a potential field to be explored. Metabolomics is the study of a set of metabolites in a given sample and can represent the metabolic functioning of a cell, tissue or organism. Metabolomics has some advantages over genomics, transcriptomics, and proteomics, as metabolites are the final result of the interactions of genes, RNAs and proteins. Considering the recent "boom" in metabolomic studies and their importance in the research agenda, we here review the topic, explaining the rationale and theory of the metabolomic approach in different areas of maternal and perinatal health research for clinical practitioners. We also demonstrate the main exploratory studies of these maternal complications, commenting on their promising findings. The potential translational application of metabolomic studies, especially for the identification of predictive biomarkers, is supported by the current findings, although they require external validation in larger datasets and with alternative methodologies.
Subject: Metabolômica
Pesquisa médica translacional
Country: Brasil
Editor: Universidade de São Paulo
Rights: Aberto
Identifier DOI: 10.6061/clinics/2019/e894
Address: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1807-59322019000100303
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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