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Type: Artigo
Title: Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
Author: Antunes, Krist Helen
Fachi, Jose Luis
de Paula, Rosemeire
da Silva, Emanuelle Fraga
Pral, Lais Passariello
dos Santos, Adara Aurea
Malaquias Dias, Greicy Brisa
Vargas, Jose Eduardo
Puga, Renato
Mayer, Fabiana Quoos
Maito, Fabio
Zarate-Blades, Carlos R.
Ajami, Nadim J.
St Ana, Marcella Ramos
Candreva, Thamiris
Rodrigues, Hosana Gomes
Schmiele, Marcio
Pedrosa Silva Clerici, Maria Teresa
Proenca-Modena, Jose Luiz
Vieira, Angelica Thomas
Mackay, Charles R.
Mansur, Daniel
Caballero, Mauricio T.
Marzec, Jacqui
Li, Jianying
Wang, Xuting
Bell, Douglas
Polack, Fernando P.
Kleeberger, Steven R.
Stein, Renato T.
Ramirez Vinolo, Marco Aurelio
Duarte de Souza, Ana Paula
Abstract: Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acetate mediated interferon-beta (IFN-beta) response by increasing expression of interferon-stimulated genes in the lung. These effects were associated with reduction of viral load and pulmonary inflammation in RSV-infected mice. Type 1 IFN signaling via the IFN-1 receptor (IFNAR) was essential for acetate antiviral activity in pulmonary epithelial cell lines and for the acetate protective effect in RSV-infected mice. Activation of Gpr43 in pulmonary epithelial cells reduced virus-induced cytotoxicity and promoted antiviral effects through IFN-beta response. The effect of acetate on RSV infection was abolished in Gpr43(-/-) mice. Our findings reveal antiviral effects of acetate involving IFN-beta in lung epithelial cells and engagement of GPR43 and IFNAR
Subject: Vírus sincicial respiratório humano
Country: Reino Unido
Editor: Springer
Rights: Aberto
Identifier DOI: 10.1038/s41467-019-11152-6
Date Issue: 2019
Appears in Collections:IB - Artigos e Outros Documentos
FEA - Artigos e Outros Documentos
FCA - Artigos e Outros Documentos

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