Please use this identifier to cite or link to this item:
|Title:||Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response|
|Author:||Antunes, Krist Helen|
Fachi, Jose Luis
de Paula, Rosemeire
da Silva, Emanuelle Fraga
Pral, Lais Passariello
dos Santos, Adara Aurea
Malaquias Dias, Greicy Brisa
Vargas, Jose Eduardo
Mayer, Fabiana Quoos
Zarate-Blades, Carlos R.
Ajami, Nadim J.
St Ana, Marcella Ramos
Rodrigues, Hosana Gomes
Pedrosa Silva Clerici, Maria Teresa
Proenca-Modena, Jose Luiz
Vieira, Angelica Thomas
Mackay, Charles R.
Caballero, Mauricio T.
Polack, Fernando P.
Kleeberger, Steven R.
Stein, Renato T.
Ramirez Vinolo, Marco Aurelio
Duarte de Souza, Ana Paula
|Abstract:||Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acetate mediated interferon-beta (IFN-beta) response by increasing expression of interferon-stimulated genes in the lung. These effects were associated with reduction of viral load and pulmonary inflammation in RSV-infected mice. Type 1 IFN signaling via the IFN-1 receptor (IFNAR) was essential for acetate antiviral activity in pulmonary epithelial cell lines and for the acetate protective effect in RSV-infected mice. Activation of Gpr43 in pulmonary epithelial cells reduced virus-induced cytotoxicity and promoted antiviral effects through IFN-beta response. The effect of acetate on RSV infection was abolished in Gpr43(-/-) mice. Our findings reveal antiviral effects of acetate involving IFN-beta in lung epithelial cells and engagement of GPR43 and IFNAR|
|Subject:||Vírus sincicial respiratório humano|
|Appears in Collections:||IB - Artigos e Outros Documentos|
FEA - Artigos e Outros Documentos
FCA - Artigos e Outros Documentos
Files in This Item:
|000460103000010.pdf||2.4 MB||Adobe PDF||View/Open|
|000476721900021.pdf||5.67 MB||Adobe PDF||View/Open|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.