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Type: Artigo
Title: Analysis of motor and respiratory function in Duchenne muscular dystrophy patients
Author: Luiz, Livia Cocato
Lima Marson, Fernando Augusto
Bresciani Almeida, Celize Cruz
Dalbo Contrera Toro, Adyleia Aparecida
Nucci, Anamarli
Ribeiro, Jose Dirceu
Abstract: Duchenne muscular dystrophy(DMD) shows motor and respiratory impairment. Methods: 19 DMD patients (DMDG) (nine ambulatory and 10 non-ambulatory) were evaluated through motor function measure (MFM), 6-minute walk test (6MWT), respiratory muscle strength, cough peak flow, spirometry and volumetric capnography (VCap) tools. Control group that performed spirometry and VCap (CG1-n = 17) were different from those that performed the 6MWT (CG2-n = 8). Results: The follow tools were assessed (p < 0.05): (i) MFM: Ambulatory patients showed higher values than non-ambulatory patients; (ii) 6MWT: DMDG walked a shorter distance and showed higher respiratory rate at rest and heart rate (HR) at rest than CG2; (iii) Spirometry: DMDG and non-ambulatory patients had minor values achieved in spirometry when compared with CG1 and ambulatory patients, respectively; (iv) VCap: DMDG when compared with CG1 showed: (< 11 years-old) lower values in VCap parameters; (> 11 years-old): higher HR and lower slope 2. There was correlation between spirometry, mainly for zFEV(1)/FVC, and MFM. Conclusion DMDG showed motor (MFM/6MWT) and respiratory (spirometry/VCap) deterioration when compared with CG. Non-ambulatory condition was associated with worse MFM and spirometry.
Subject: Distrofia muscular de Duchenne
Testes de função respiratória
Country: Holanda
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.resp.2019.01.009
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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