Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337627
Type: Artigo
Title: Autonomic dysfunction is frequent and disabling in non-paraneoplastic sensory neuronopathies
Author: Muro Martinez, Alberto Rolim
Martins, Melina Pazian
Ribeiro de Rezende, Thiago Junqueira
Faber, Ingrid
Gonzalez Salazar, Carelis del Valle
Girotto Takazaki, Karen Antonia
Nucci, Anamarli
Franca, Marcondes Cavalcante, Jr.
Abstract: Sensory neuronopathies (SN) are characterized by asymmetric non-length dependent sensory deficits and sensory ataxia. Autonomic dysfunction in SN was not yet evaluated regarding its frequency, characteristics and relationship to sensory deficits. To address these issues, we performed a comprehensive clinical and neurophysiological evaluation of a large cohort of patients with non-paraneoplastic SN (np-SN). Methods: We enrolled 50 consecutive patients with npSN and 32 age/sex-matched healthy controls. They were clinically evaluated (SCOPA-Aut scale) and underwent neurophysiological autonomic assessment (quantitative sudomotor axon reflex test, heart rate variability and sympathetic skin response). Results: Mean age of patients was 50.9 +/- 10.3 years and there were 18 men. npSN patients had higher SCOPA-Aut scores than controls (26.63 +/- 12.72 vs. 12.66 +/- 9.11, p < .001). QSART was abnormal in 92% of the patients - sweat volumes in all examined sites were smaller among patients (p < .001). Cardiovascular autonomic neuropathy was more frequent in these patients as well (p < .001). Conclusion: Altogether our results suggest that autonomic dysfunction in distinct domains is frequent in npSN patients. These findings suggest that the clinical picture of npSN is related to a double neuronopathy: sensory and autonomic.
Subject: Atrofia muscular
Country: Holanda
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.jns.2019.05.018
Address: https://www.sciencedirect.com/science/article/pii/S0022510X19302345
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos

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