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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCoelho Júnior, Hélio José-
dc.typeArtigopt_BR
dc.titleThe metabolomics side of frailty : toward personalized medicine for the agedpt_BR
dc.contributor.authorPicca, Anna-
dc.contributor.authorCoelho-Junior, Hélio José-
dc.contributor.authorCesari, Matteo-
dc.contributor.authorMarini, Federico-
dc.contributor.authorMiccheli, Alfredo-
dc.contributor.authorGervasoni, Jacopo-
dc.contributor.authorBossola, Maurizio-
dc.contributor.authorLandi, Francesco-
dc.contributor.authorBernabei, Roberto-
dc.contributor.authorMarzetti, Emanuele-
dc.contributor.authorCalvani, Riccardo-
dc.subjectAnálise multivariadapt_BR
dc.subjectMarcadores biológicospt_BR
dc.subject.otherlanguageBiological markerspt_BR
dc.subject.otherlanguageMultivariate analysispt_BR
dc.description.abstractFrailty encompasses several domains (i.e., metabolic, physical, cognitive). The multisystem derangements underlying frailty pathophysiology, its phenotypic heterogeneity, and the fluctuations of individuals across severity states have hampered a comprehensive appraisal of the condition. Circulating biomarkers emerged as an alleged tool for capturing this complexity and, as proxies for organismal metabolic changes, may hold the advantages of: 1) supporting diagnosis, 2) tracking the progression, 3) assisting healthcare professionals in clinical and therapeutic decision-making, and 4) verifying the efficacy of an intervention before measurable clinical manifestations occur. Among available analytical tools, metabolomics are able to identify and quantify the (ideally) whole repertoire of small molecules in biological matrices (i.e., cells, tissues, and biological fluids). Results of metabolomics analysis may define the final output of genome-environment interactions at the individual level. This entire collection of metabolites is called “metabolome” and is highly dynamic. Here, we discuss how monitoring the dynamics of metabolic profiles may provide a read-out of the environmental and clinical disturbances affecting cell homeostasis in frailty-associated conditionspt_BR
dc.relation.ispartofExperimental gerontologypt_BR
dc.relation.ispartofabbreviationExp. gerontol.pt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-10-
dc.date.monthofcirculationOct.pt_BR
dc.language.isoengpt_BR
dc.description.volume126pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0531-5565pt_BR
dc.identifier.eissn1873-6815pt_BR
dc.identifier.doi10.1016/j.exger.2019.110692pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0531556519304322pt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsordocumentnumber001pt_BR
dc.date.available2020-03-26T20:10:46Z-
dc.date.accessioned2020-03-26T20:10:46Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-03-26T20:10:46Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T14:19:25Z : No. of bitstreams: 1 000489688900014.pdf: 362332 bytes, checksum: 55d8f504a77fb8e6e20532436776aaa9 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-26T20:10:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-10en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337599-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.unidadeFaculdade de Educação Físicapt_BR
dc.subject.keywordMetabotypept_BR
dc.subject.keywordEndophenotypept_BR
dc.subject.keywordOmicspt_BR
dc.subject.keywordPerson-tailoredpt_BR
dc.identifier.source000489688900014pt_BR
dc.creator.orcid0000-0001-7482-9514pt_BR
dc.type.formArtigo de Revisãopt_BR
dc.identifier.articleid110692pt_BR
dc.description.sponsorNoteThis work was supported by Innovative Medicine Initiative-Joint Undertaking (IMI-JU #115621), Intramural Research Grants from the Università Cattolica del Sacro Cuore (D3.2 2013 and D3.2 2015), and the nonprofit research foundation “Centro Studi Achille e Linda Lorenzon”. Hélio José Coelho-Junior is funded by a scholarship from the Brazilian federal government (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 001)pt_BR
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