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Type: Artigo
Title: The metabolomics side of frailty : toward personalized medicine for the aged
Author: Picca, Anna
Coelho-Junior, Hélio José
Cesari, Matteo
Marini, Federico
Miccheli, Alfredo
Gervasoni, Jacopo
Bossola, Maurizio
Landi, Francesco
Bernabei, Roberto
Marzetti, Emanuele
Calvani, Riccardo
Abstract: Frailty encompasses several domains (i.e., metabolic, physical, cognitive). The multisystem derangements underlying frailty pathophysiology, its phenotypic heterogeneity, and the fluctuations of individuals across severity states have hampered a comprehensive appraisal of the condition. Circulating biomarkers emerged as an alleged tool for capturing this complexity and, as proxies for organismal metabolic changes, may hold the advantages of: 1) supporting diagnosis, 2) tracking the progression, 3) assisting healthcare professionals in clinical and therapeutic decision-making, and 4) verifying the efficacy of an intervention before measurable clinical manifestations occur. Among available analytical tools, metabolomics are able to identify and quantify the (ideally) whole repertoire of small molecules in biological matrices (i.e., cells, tissues, and biological fluids). Results of metabolomics analysis may define the final output of genome-environment interactions at the individual level. This entire collection of metabolites is called “metabolome” and is highly dynamic. Here, we discuss how monitoring the dynamics of metabolic profiles may provide a read-out of the environmental and clinical disturbances affecting cell homeostasis in frailty-associated conditions
Subject: Análise multivariada
Marcadores biológicos
Country: Estados Unidos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.exger.2019.110692
Date Issue: Oct-2019
Appears in Collections:FEF - Artigos e Outros Documentos

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