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Type: Artigo
Title: Evaluation of proanthocyanidin- crosslinked sericin/alginate blend for ketoprofen extended release
Author: Freitas, Emanuelle Dantas de
Lima, Beatriz Mayumi
Rosa, Paulo Cesar Pires
Silva, Meuris Gurgel Carlos da
Vieira, Melissa Gurgel Adeodato
Abstract: Sericin and alginate blend has shown good results for obtaining sustained release dosage forms. In the case of ketoprofen, it was necessary to resort to the use of the proanthocyanidin (PA) as crosslinking agent in order to achieve this same goal. Thus, various formulations were developed by adding different initial amounts of PA to the sericin and alginate blend with incorporated ketoprofen. The best results for drug loading, entrapment efficiency and release prolongation were obtained for the particle with the lowest amount of PA (0.5%). Mathematical modeling has indicated that different mechanisms may be involved in drug release, especially a complex release mechanism, with polymer dissolution and polymer chain relaxation allowing drug release. Particles characterization confirmed the incorporation of ketoprofen into the sericin, alginate and proanthocyanidin blend. It was verified that there was no interaction between them and there were no major changes in the physicochemical properties of the drug
Subject: Alginatos
Country: Holanda
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.apt.2019.04.031
Date Issue: 2019
Appears in Collections:FEQ - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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