Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337525
Type: Artigo
Title: Role of epigenetic mechanisms in cisplatin-induced toxicity
Author: Quintanilha, Julia Coelho Franca
Saavedra, Kathleen Francinette
Visacri, Marilia Berlofa
Moriel, Patricia
Salazar, Luis A.
Abstract: Cisplatin (CDDP) is a highly effective antineoplastic agent, widely used in the treatment of various malignant tumors. However, its major problems are side effects associated to toxicity. Considerable inter-individual differences have been reported for CDDP-induced toxicity due to genetic and epigenetic factors. Genetic causes are well described; however, epigenetic modifications are not fully addressed. In the last few years, many evidences were found linking microRNA to the development of CDDP-mediated toxicity, particularly nephrotoxicity. In this review, we described how genetic and epigenetic modifications can be important determinants for the development of toxicity in patients treated with CDDP, and how these alterations may be interesting biomarkers for monitoring toxicity induced by CDDP. Considering the validation in different studies, we suggest that miR-34a, -146b, -378a, -192, and -193 represent an attractive study group to evaluate potential biomarkers to detect CDDP-related nephrotoxicity
Subject: Cisplatino
Epigenômica
MicroRNAs
Metilação
Country: Irlanda
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.critrevonc.2019.03.004
Address: https://www.sciencedirect.com/science/article/pii/S1040842818303913
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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