Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337505
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSousa, Jossaria Pereira de-
dc.contributor.authorunicampBarbosa-Martins, Luiz Filipe-
dc.contributor.authorunicampPuppin-Rontani, Regina Maria-
dc.typeArtigopt_BR
dc.titleThe self-assembling peptide P-11-4 prevents collagen proteolysis in dentinpt_BR
dc.contributor.authorde Sousa, J. P.-
dc.contributor.authorCarvalho, R. G.-
dc.contributor.authorBarbosa-Martins, L. F.-
dc.contributor.authorTorquato, R. J. S.-
dc.contributor.authorMugnol, K. C. U.-
dc.contributor.authorNascimento, F. D.-
dc.contributor.authorTersariol, I. L. S.-
dc.contributor.authorPuppin-Rontani, R. M.-
dc.subjectBiomateriaispt_BR
dc.subject.otherlanguageBiomaterialspt_BR
dc.description.abstractThe major goal in restorative dentistry is to develop a true regenerative approach that fully recovers hydroxyapatite crystals within the caries lesion. Recently, a rationally designed self-assembling peptide P-11-4 (Ace-QQRFEWEFEQQ-NH2) has been developed to enhance remineralization on initial caries lesions, yet its applicability on dentin tissues remains unclear. Thus, the present study investigated the interaction of P-11-4 with the organic dentin components as well as the effect of P-11-4 on the proteolytic activity, mechanical properties of the bonding interface, and nanoleakage evaluation to artificial caries-affected dentin. Surface plasmon resonance and atomic force microscopy indicated that P-11-4 binds to collagen type I fibers, increasing their width from 214 +/- 4 nm to 308 +/- 5 nm (P < 0.0001). P-11-4 also increased the resistance of collagen type I fibers against the proteolytic activity of collagenases. The immediate treatment of artificial caries-affected dentin with P-11-4 enhanced the microtensile bonding strength of the bonding interface (P < 0.0001), reaching values close to sound dentin and decreasing the proteolytic activity at the hybrid layer; however, such effects decreased after 6 mo of water storage (P < 0.05). In conclusion, P-11-4 interacts with collagen type I, increasing the resistance of collagen fibers to proteolysis, and improves stability of the hybrid layer formed by artificial caries-affected dentinpt_BR
dc.relation.ispartofJournal of dental researchpt_BR
dc.relation.ispartofabbreviationJ. dent. res.pt_BR
dc.publisher.cityThousand Oaks, CApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherSagept_BR
dc.date.issued2019-
dc.date.monthofcirculationMar.pt_BR
dc.language.isoengpt_BR
dc.description.volume98pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage347pt_BR
dc.description.lastpage354pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0022-0345pt_BR
dc.identifier.eissn1544-0591pt_BR
dc.identifier.doi10.1177/0022034518817351pt_BR
dc.identifier.urlhttps://journals.sagepub.com/doi/10.1177/0022034518817351pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber2013/05822-9; 2014/22899-8; 2015/12660-0; 2013/05822-9; 2014//22899-8; 2015/03964-6pt_BR
dc.date.available2020-03-26T19:27:42Z-
dc.date.accessioned2020-03-26T19:27:42Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-03-26T19:27:42Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T14:16:49Z : No. of bitstreams: 1 000459288100012.pdf: 1020486 bytes, checksum: 64425b2f5d8538e4856d6e9e440a45a5 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-26T19:27:42Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337505-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Odontologia Infantilpt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordOperative dentristrypt_BR
dc.subject.keywordProtease inhibitorspt_BR
dc.subject.keywordTissue engineeringpt_BR
dc.subject.keywordCariespt_BR
dc.identifier.source000459288100012pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-2123-2850pt_BR
dc.creator.orcid0000-0002-1218-5159pt_BR
dc.type.formArtigopt_BR
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