Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/337497
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampRodrigues, Plínio Ribeiro-
dc.contributor.authorunicampVieira, Roniérik Pioli-
dc.typeArtigopt_BR
dc.titleAdvances in atom-transfer radical polymerization for drug delivery applicationspt_BR
dc.contributor.authorRodrigues, Plinio Ribeiro-
dc.contributor.authorVieira, Ronierik Pioli-
dc.subjectBiomateriaispt_BR
dc.subject.otherlanguageBiomaterialspt_BR
dc.description.abstractThe availability of appropriate materials is the main requisite for the design of controlled-release drug delivery systems (DDS), such as nanoparticles, micelles, microparticles, hydrogels and bioconjugates. These delivery platforms must be biocompatible and present appropriate mechanical, physical, chemical and biological properties, allowing the desired control over drug loading and release and granting the benefits of this therapeutic administration route. Atom transfer radical polymerization (ATRP) is presently one of the most used methods of controlled polymerization, applied to synthesize well-defined functional materials and complex polymeric architectures with programmed molecular weights and low dispersity. This review features recent advances in the synthesis of DDS by ATRP, their preparation methods, characteristics and toxicity challenges due to residual metal catalysts. A brief description of controlled polymer architectures, drug loading and release mechanisms, and ATRP techniques is presented to contextualize the readers. It is noted that precise engineering of polymeric materials over molecular architecture, granted by ARTP, is being translated to customized physical properties, allowing fine control over fundamental parameters for the design of DDSpt_BR
dc.relation.ispartofEuropean polymer journalpt_BR
dc.relation.ispartofabbreviationEur. polym. j.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-
dc.date.monthofcirculationJunept_BR
dc.language.isoengpt_BR
dc.description.volume115pt_BR
dc.description.firstpage45pt_BR
dc.description.lastpage58pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0014-3057pt_BR
dc.identifier.eissn1873-1945pt_BR
dc.identifier.doi10.1016/j.eurpolymj.2019.03.023pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0014305719302812pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.description.sponsordocumentnumber2018/02508-5pt_BR
dc.date.available2020-03-26T19:04:34Z-
dc.date.accessioned2020-03-26T19:04:34Z-
dc.description.provenanceSubmitted by Sanches Olivia (olivias@unicamp.br) on 2020-03-26T19:04:34Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-20T14:18:03Z : No. of bitstreams: 1 000471736400007.pdf: 1990287 bytes, checksum: 76b98aae48074e9b6e82d93e2731cbf2 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-03-26T19:04:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2019en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/337497-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Engenharia de Materiais e Bioprocessospt_BR
dc.contributor.unidadeFaculdade de Engenharia Químicapt_BR
dc.subject.keywordATRPpt_BR
dc.subject.keywordNanoparticlespt_BR
dc.subject.keywordMicellespt_BR
dc.subject.keywordMicroparticlespt_BR
dc.subject.keywordHydrogelspt_BR
dc.subject.keywordBioconjugatespt_BR
dc.identifier.source000471736400007pt_BR
dc.creator.orcid0000-0002-6652-5470pt_BR
dc.creator.orcid0000-0002-1887-3120pt_BR
dc.type.formArtigopt_BR
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